Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Y Wang, X Wu, Z Ren, Y Li, W Zou, J Chen… - Drug Resistance …, 2023 - Elsevier
Abstract Development of resistance to chemotherapy in cancer continues to be a major
challenge in cancer management. Ferroptosis, a unique type of cell death, is mechanistically …

Metformin improves ovarian cancer sensitivity to paclitaxel and platinum-based drugs: a review of in vitro findings

G Tossetta - International Journal of Molecular Sciences, 2022 - mdpi.com
Ovarian cancer is one of the most dangerous gynecologic cancers worldwide, showing a
high fatality rate and recurrence due to diagnosis at an advanced stage of the disease and …

Codelivery of phytochemicals with conventional anticancer drugs in form of nanocarriers

G Kumar, T Virmani, A Sharma, K Pathak - Pharmaceutics, 2023 - mdpi.com
Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the
heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various …

Reactive oxygen species mediated apoptotic death of colon cancer cells: Therapeutic potential of plant derived alkaloids

VK Nelson, MV Nuli, J Mastanaiah… - Frontiers in …, 2023 - frontiersin.org
Colorectal cancer (CRC) is one of the most deaths causing diseases worldwide. Several risk
factors including hormones like insulin and insulin like growth factors (eg, IGF-1) have been …

Gastrointestinal Degradation and Toxicity of Disinfection Byproducts in Drinking Water Using In Vitro Models and the Roles of Gut Microbiota

J Yin, D Li, T Zheng, B Hu, P Wang - Environmental Science & …, 2023 - ACS Publications
Disinfection byproducts (DBPs) in drinking water are mainly exposed to the human body
after oral ingestion and degradation in the gastrointestinal tract. The role of gastrointestinal …

Exploring Synergistic Interactions between Natural Compounds and Conventional Chemotherapeutic Drugs in Preclinical Models of Lung Cancer

M Boța, L Vlaia, AR Jîjie, I Marcovici, F Crişan… - Pharmaceuticals, 2024 - mdpi.com
In the current work, the synergy between natural compounds and conventional
chemotherapeutic drugs is comprehensively reviewed in light of current preclinical research …

Network pharmacology-based anti-colorectal cancer activity of piperlonguminine in the ethanolic root extract of Piper longum L

I Singh, R Das, A Kumar - Medical Oncology, 2023 - Springer
Colorectal cancer (CRC) has the second highest incidence and fatality rates of any
malignancy, at 10.2 and 9.2%, respectively. Plants and plants-based products for thousands …

Genomic-driven nutritional interventions for radiotherapy-resistant rectal cancer patient

J Southern, G Gonzalez, P Borgas, L Poynter… - Scientific Reports, 2023 - nature.com
Radiotherapy response of rectal cancer patients is dependent on a myriad of molecular
mechanisms including response to stress, cell death, and cell metabolism. Modulation of …

The chemo-sensitizing effect of doxorubicin of apple extract-enriched triterpenic complex on human colon adenocarcinoma and human glioblastoma cell lines

A Braciuliene, V Janulis, V Petrikaite - Pharmaceutics, 2022 - mdpi.com
Cancer cells' resistance to anticancer drugs represents a major clinical problem and the
most important failure of treatment. Combination chemotherapy is more effective than …

NRF2 and Bip interconnection mediates resistance to the organometallic Ruthenium-Cymene Bisdemethoxycurcumin complex cytotoxicity in colon cancer cells

A Garufi, R Pettinari, F Marchetti, M Cirone, G D'Orazi - Biomedicines, 2023 - mdpi.com
Organometallic ruthenium (Ru)(II)-cymene complexes display promising pharmacological
properties and might represent alternative therapeutic agents in medical applications …