Introduction The nose-to-brain route has been widely investigated to improve drug targeting
to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles …

The intranasal route has proven to be a reliable and promising route for delivering
therapeutics to the central nervous system (CNS), averting the blood–brain barrier (BBB) …

Pyridine compounds are one of the most important heterocyclic derivatives showing wide
ranges in biological and pharmacological activities. Green chemistry eliminates or reduces …

Despite enormous advancements in its management, cancer is the world's primary cause of
mortality. Therefore, tremendous strides were made to produce intelligent theranostics with …

Nanofibers (NFs) have proven to be very attractive tool as drug delivery plateform among the
different plethora of nanosystems, owing to their unique features. They exhibit two-and three …

Rivastigmine hydrogen tartrate (RIV-HT) is given orally for Alzheimer's disease. However,
oral therapy shows low brain bioavailability, short half-life and gastrointestinal-mediated …

Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as
neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some …

Mirtazapine (MZPc) is an antidepressant drug which is approved by the FDA. It has low
bioavailability, which is only 50%, in spite of its rapid absorption when orally administered …

Background Recent advances in clinical transformation research have focused on
chemodynamic theranostics as an emerging strategy for tackling cancer. Nevertheless, its …

Background: Low bioavailability, highly variable blood levels and poor clinical efficacy of
Aripiprazole (ARP) are primarily linked to its hydrophobic nature. This investigation focused …