Integrins are cell adhesion and signalling proteins crucial to a wide range of biological
functions. Effective marketed treatments have successfully targeted integrins αIIbβ3 …

Transforming growth factor-β (TGFβ) signalling controls multiple cell fate decisions during
development and tissue homeostasis; hence, dysregulation of this pathway can drive …

T cells and natural killer (NK) cells have complementary roles in tumor immunity, and dual T
cell and NK cell attack thus offers opportunities to deepen the impact of immunotherapy …

Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

Cancer immunotherapy shows limited efficacy against many solid tumors that originate from
epithelial tissues, including triple-negative breast cancer (TNBC). We identify the SOX4 …

The TGF-β signaling pathway governs key cellular processes under physiologic conditions
and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional …

The basement membrane is an important extracellular matrix that is found in all epithelial
and endothelial tissues. It maintains tissue integrity, serves as a barrier to cells and to …

Transforming growth factor-β (TGF-β) signaling regulates multiple physiological processes,
such as cell proliferation, differentiation, immune homeostasis, and wound healing. Besides …

Transforming growth factor-β (TGF-β) signaling shows important roles in both physiology
and pathology, especially in the progression of inflammatory diseases including cancer …

Chronic kidney disease (CKD) represents a leading cause of death in the United States.
There is no cure for this disease, with current treatment strategies relying on blood pressure …