Macrophages represent a key component of the tumor microenvironment (TME) and are
largely associated with poor prognosis. Therapeutic targeting of macrophages has …

The Forkhead box O3 (FOXO3) transcription factor regulates the expression of genes critical
for diverse cellular functions in homeostasis. Diminished FOXO3 activity is associated with …

The retina is a high-metabolism tissue composed of various cell types with complex
functions that relies heavily on the blood supply to maintain homeostasis. Retinal ischemia …

Mounting evidence suggests that high-fat diet (HFD) consumption increases the risk for
depression, but the neurophysiological mechanisms involved remain to be elucidated. Here …

Obesity increases the morbidity and mortality of traumatic brain injury (TBI). Detailed
analyses of transcriptomic changes in the brain and adipose tissue were performed to …

Background Lipids are a key nutrient source for the growth and reproduction of
Mycobacterium tuberculosis (Mtb). Urine-derived extracellular vesicles (EVs), because of its …

Non-alcoholic fatty liver disease (NAFLD) is a type of steatosis commonly associated with
obesity, dyslipidemia, hypertension, and diabetes. Other diseases such as inherited alpha-1 …

So far it is thanks to antibiotics that illnesses, such as Tuberculosis (TB), are treatable.
However, antimicrobial misuse combined with Mycobacterium tuberculosis phenotypic …

The removal of the toxic oxidized cholesterol, 7-ketocholesterol (7KC), from cells through the
administration of therapeutics has the potential to treat atherosclerosis and various other …

Interphase nuclear rupture is a known driver of DNA damage and may ultimately lead to
genetic instability promoting cell dysfunction and cancer progression. As the structural …