[HTML][HTML] The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases
CD38 (Cluster of Differentiation 38) is a multifunctional ecto-enzyme that metabolizes NAD+
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
and mediates nicotinamide dinucleotide (NAD+) and extracellular nucleotide homeostasis …
The CD38 glycohydrolase and the NAD sink: implications for pathological conditions
JD Zeidler, KA Hogan, G Agorrody… - … of Physiology-Cell …, 2022 - journals.physiology.org
Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …
Lisaftoclax (APG-2575) is a novel BCL-2 inhibitor with robust antitumor activity in preclinical models of hematologic malignancy
Purpose: Development of B-cell lymphoma 2 (BCL-2)–specific inhibitors poses unique
challenges in drug design because of BCL-2 homology domain 3 (BH3) shared homology …
challenges in drug design because of BCL-2 homology domain 3 (BH3) shared homology …
[HTML][HTML] The extracellular NADome modulates immune responses
V Audrito, VG Messana, L Brandimarte… - Frontiers in …, 2021 - frontiersin.org
The term NADome refers to the intricate network of intracellular and extracellular enzymes
that regulate the synthesis or degradation of nicotinamide adenine dinucleotide (NAD) and …
that regulate the synthesis or degradation of nicotinamide adenine dinucleotide (NAD) and …
CD38 in the age of COVID-19: a medical perspective
AL Horenstein, AC Faini… - Physiological Reviews, 2021 - journals.physiology.org
This medical review addresses the hypothesis that CD38/NADase is at the center of a
functional axis (ie, intracellular Ca2+ mobilization/IFNγ response/reactive oxygen species …
functional axis (ie, intracellular Ca2+ mobilization/IFNγ response/reactive oxygen species …
[HTML][HTML] The key role of NAD+ in anti-tumor immune response: an update
F Morandi, AL Horenstein, F Malavasi - Frontiers in Immunology, 2021 - frontiersin.org
Nicotinamide adenine dinucleotide (NAD+) is an important molecule that functions as a co-
enzyme in numerous metabolic processes. Generated both through de novo synthesis and …
enzyme in numerous metabolic processes. Generated both through de novo synthesis and …
Targeting CD38 is lethal to Breg-like chronic lymphocytic leukemia cells and Tregs, but restores CD8+ T-cell responses
Patients with chronic lymphocytic leukemia (CLL) are characterized by monoclonal
expansion of CD5+ CD23+ CD27+ CD19+ κ/λ+ B lymphocytes and are clinically noted to …
expansion of CD5+ CD23+ CD27+ CD19+ κ/λ+ B lymphocytes and are clinically noted to …
[HTML][HTML] Recent research progress of chiral small molecular antitumor-targeted drugs approved by the FDA from 2011 to 2019
X Chu, Y Bu, X Yang - Frontiers in Oncology, 2021 - frontiersin.org
Chiral drugs usually contain chiral centers, which are present as single enantiomers or
racemates. Compared with achiral drugs, they have significant advantages in safety and …
racemates. Compared with achiral drugs, they have significant advantages in safety and …
[HTML][HTML] The Many facets of CD38 in Lymphoma: from tumor–microenvironment cell interactions to acquired resistance to immunotherapy
E Calabretta, C Carlo-Stella - Cells, 2020 - mdpi.com
The CD38 antigen is expressed in several hematological malignancies, and the anti-CD38
monoclonal antibodies Daratumumab and Isatuximab have an established role in the …
monoclonal antibodies Daratumumab and Isatuximab have an established role in the …
[HTML][HTML] The circular life of human CD38: from basic science to clinics and back
Monoclonal antibodies (mAbs) were initially considered as a possible “magic bullet” for in
vivo elimination of tumor cells. mAbs represented the first step: however, as they were …
vivo elimination of tumor cells. mAbs represented the first step: however, as they were …