Magnesium isoglycyrrhizinate (MgIG) is a magnesium salt of the 18-α glycyrrhizic acid
stereoisomer that has exhibited hepato-protective effects and has anti-inflammatory …

Due to aging populations and changes in lifestyle, cardiovascular diseases including
cardiomyopathy, hypertension, and atherosclerosis, are the leading causes of death …

Background Single ventricle (SV) congenital heart disease is fatal without intervention, and
eventual heart failure is a major cause of morbidity and mortality. Although there are no …

Mechanical pressure overload and other stimuli often contribute to heart hypertrophy, a
significant factor in the induction of heart failure. The UDP-glucose ceramide …

Lupus nephritis (LN) is a serious complication for many patients who develop systemic lupus
erythematosus, which primarily afflicts women. Our studies to identify biomarkers and the …

Abstract Background Prostate cancer (PCa) is an age‐related malignancy with a high
incidence and mortality rate due to lack of efficacy drugs for its therapy in late castration …

This review explores the crucial role of glycosphingolipids (GSLs) in the context of
cardiovascular diseases (CVDs), focusing on their biosynthesis, metabolic pathways, and …

X-linked adrenomyeloneuropathy (AMN) is an inherited neurometabolic disorder caused by
malfunction of the ABCD1 gene, characterized by slowly progressing spastic paraplegia …

Abstract D-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP), a
glycosphingolipid synthesis inhibitor, holds promise for the treatment of atherosclerosis and …

With recent advancements of analytical techniques and mass spectrometric
instrumentations, proteomics has been widely exploited to study the regulation of protein …