Aging in multiple sclerosis: from childhood to old age, etiopathogenesis, and unmet needs: a narrative review

N Capasso, E Virgilio, A Covelli, B Giovannini… - Frontiers in …, 2023 - frontiersin.org
Multiple sclerosis (MS) primarily affects adult females. However, in the last decades, rising
incidence and prevalence have been observed for demographic extremes, such as pediatric …

Molecular biomarkers and cognitive impairment in multiple sclerosis: state of the field, limitations, and future direction–a systematic review and meta-analysis

TD Rademacher, SG Meuth, H Wiendl, A Johnen… - Neuroscience & …, 2023 - Elsevier
Objective Multiple sclerosis (MS) is associated with cognitive impairment (CI) such as
slowed information processing speed (IPS). Currently, no immunocellular or molecular …

Cerebrospinal fluid biomarkers and cognitive functions at multiple sclerosis diagnosis

E Virgilio, D Vecchio, I Crespi, C Puricelli, P Barbero… - Journal of …, 2022 - Springer
Cognitive impairment (CI) is a frequent and disabling symptom in Multiple Sclerosis (MS).
Axonal damage may contribute to CI development from early stages. Nevertheless, no …

The role of Tau beyond Alzheimer's disease: a narrative review

E Virgilio, F De Marchi, E Contaldi, U Dianzani… - Biomedicines, 2022 - mdpi.com
Nowadays, there is a need for reliable fluid biomarkers to improve differential diagnosis,
prognosis, and the prediction of treatment response, particularly in the management of …

Baseline serum neurofilament light chain levels differentiate aggressive from benign forms of relapsing–remitting multiple sclerosis: a 20-year follow-up cohort

P Arroyo Pereiro, A Muñoz-Vendrell, I León Moreno… - Journal of …, 2024 - Springer
Background and objectives Serum biomarkers are emerging as useful prognostic tools for
multiple sclerosis (MS); however, long-term studies are lacking. We aimed to evaluate the …

Serum-based biomarkers in neurodegeneration and multiple sclerosis

P LoPresti - Biomedicines, 2022 - mdpi.com
Multiple Sclerosis (MS) is a debilitating disease with typical onset between 20 and 40 years
of age, so the disability associated with this disease, unfortunately, occurs in the prime of life …

Neurodegeneration and convergent factors contributing to the deterioration of the cytoskeleton in Alzheimer's disease, cerebral ischemia and multiple sclerosis

JA Gutiérrez-Vargas… - Biomedical …, 2022 - spandidos-publications.com
The cytoskeleton is the main intracellular structure that determines the morphology of
neurons and maintains their integrity. Therefore, disruption of its structure and function may …

Cognitive Decline in Older People with Multiple Sclerosis—A Narrative Review of the Literature

HS Chiang, A Khera, BE Stopschinski, O Stuve… - Geriatrics, 2022 - mdpi.com
Several important questions regarding cognitive aging and dementia in older people with
multiple sclerosis (PwMS) are the focus of this narrative review: Do older PwMS have worse …

Systematic search for novel circulating biomarkers associated with extracellular vesicles in Alzheimer's disease: Combining literature screening and database mining …

D Vogrinc, K Goričar, T Kunej, V Dolžan - Journal of personalized …, 2021 - mdpi.com
miRNAs play an important role in neurodegenerative diseases. Many miRNA-target gene
interactions (MTI) have been experimentally confirmed and associated with Alzheimer's …

[HTML][HTML] A Review of Biomarkers of Amyotrophic Lateral Sclerosis: A Pathophysiologic Approach

RS Alshehri, AR Abuzinadah, MS Alrawaili… - International Journal of …, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of upper and lower motor neurons. The heterogeneous nature of …