Simple Summary Adrenocortical cancer is a very rare form of endocrine cancer with dismal
prognosis. Preclinical models such as cell lines, organoids, and mouse models are essential …

The basic helix–loop–helix transcription factor (bHLH TF) family is involved in tissue
development, cell differentiation, and disease. These factors have transcriptionally positive …

Adrenal glands and gonads share a common primordium (AGP), but the molecular events
driving differentiation are poorly understood. Here we demonstrate that the Wilms tumor …

Background To date, there is no effective therapy for patients with advanced/metastatic
adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in …

The lineage relationships of fetal adrenal cells and adrenal capsular cells to the
differentiated adrenal cortex are not fully understood. Existing data support a role for each …

The body of knowledge surrounding reproductive development spans the fields of genetics,
anatomy, physiology and biomedicine, to build a comprehensive understanding of the later …

Abstract Transcription factor 21 (TCF21) is a member of the basic helix-loop-helix (bHLH)
transcription factors that mediate cell fate and differentiation by orchestrating temporal and …

This review summarizes key knowledge regarding the development, growth, and growth
disorders of the adrenal cortex from a molecular perspective. The adrenal gland consists of …

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists,
clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists …

The cortex of the adrenal gland is organized into concentric zones that produce distinct
steroid hormones essential for body homeostasis in mammals. Mechanisms leading to the …