The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

Cardiovascular disease is the leading cause of death worldwide. Although investment in
drug discovery and development has been sky-rocketing, the number of approved drugs has …

Cardiovascular diseases (CVD) constitute a major fraction of the current major global
diseases and lead to about 30% of the deaths, ie, 17.9 million deaths per year. CVD include …

Since the advent of the generation of human induced pluripotent stem cells (hiPSCs),
numerous protocols have been developed to differentiate hiPSCs into cardiomyocytes and …

The engineering of 3-dimensional (3D) heart muscles has undergone exciting progress for
the past decade. Profound advances in human stem cell biology and technology, tissue …

Aims Sarcomeric gene mutations frequently underlie hypertrophic cardiomyopathy (HCM), a
prevalent and complex condition leading to left ventricle thickening and heart dysfunction …

More than 350 individual MYPBC3 mutations have been identified in patients with inherited
hypertrophic cardiomyopathy (HCM), thus representing 40–50% of all HCM mutations …

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-
CMs) is essential for their effective application in models of cardiac toxicity and disease …

Drug development is time-and cost-intensive and, despite extensive efforts, still hampered
by the limited value of current preclinical test systems to predict side effects, including …

The sarcomeric proteins represent the structural building blocks of heart muscle, which are
essential for contraction and relaxation. During recent years, it has become evident that …