G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

G-quadruplexes (G4s) are non-canonical nucleic acid secondary structures that have
gathered significant interest in medicinal chemistry over the past two decades due to their …

Besides the well-known DNA double-helix, non-canonical nucleic acid structures regulate
crucial biological activities. Among these oddities, guanine-rich DNA sequences can form …

Viral genomes are enriched with G-quadruplexes (G4s), non-canonical structures formed in
DNA or RNA upon assembly of four guanine stretches into stacked quartets. Because of …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated …

Lead pollution are critical concerns for food safety and human health. Herein, a ratiometric
metal-induced G-quadruplex polymorphism was introduced to construct aptamer probes …

Metal ions are essential components for the survival of living organisms. For most species,
intracellular and extracellular ionic conditions differ significantly. As G-quadruplexes (G4s) …

ABSTRACT Guanine-quadruplex structures (G4) are unusual nucleic acid conformations
formed by guanine-rich DNA and RNA sequences and known to control gene expression …

Due to the advantages of its numerous modification sites, predictable structure, high thermal
stability, and excellent biocompatibility, DNA is the ideal choice as a key component of …

Abstract G-quadruplexes (G4) are special nucleic acid structures with diverse
conformational polymorphisms. Selective targeting of G-quadruplex conformations and …