2-Aminobenzothiazoles in anticancer drug design and discovery
G Huang, T Cierpicki, J Grembecka - Bioorganic chemistry, 2023 - Elsevier
Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …
research efforts have been made to develop new chemical entities with improved anticancer …
Structure‐based drug design for cytochrome P450 family 1 inhibitors
Z Dutkiewicz, R Mikstacka - Bioinorganic chemistry and …, 2018 - Wiley Online Library
Cytochromes P450 are a class of metalloproteins which are responsible for electron transfer
in a wide spectrum of reactions including metabolic biotransformation of endogenous and …
in a wide spectrum of reactions including metabolic biotransformation of endogenous and …
In silico screening of hundred phytocompounds of ten medicinal plants as potential inhibitors of nucleocapsid phosphoprotein of COVID-19: an approach to prevent …
R Rolta, R Yadav, D Salaria, S Trivedi… - Journal of …, 2021 - Taylor & Francis
Currently, there is no specific treatment to cure COVID-19. Many medicinal plants have
antiviral, antioxidant, antibacterial, antifungal, anticancer, wound healing etc. Therefore, the …
antiviral, antioxidant, antibacterial, antifungal, anticancer, wound healing etc. Therefore, the …
Virtual screening, ADMET prediction and dynamics simulation of potential compounds targeting the main protease of SARS-CoV-2
The coronavirus disease-2019 caused by a novel SARS CoV-2 virus has emerged as a
global threat. Still, no drugs are available for its treatment. The main protease is the most …
global threat. Still, no drugs are available for its treatment. The main protease is the most …
Ensemble docking and molecular dynamics identify knoevenagel curcumin derivatives with potent anti-EGFR activity
Epidermal growth factor receptor tyrosine kinase (EGFR-TK) is an attractive target for cancer
therapy. Despite a number of effective EGFR inhibitors that are constantly expanding and …
therapy. Despite a number of effective EGFR inhibitors that are constantly expanding and …
Benzothiazoles: how relevant in cancer drug design strategy?
Heterocyclic compounds, analogs and derivatives have attracted attention due to their
diverse biological and pharmacological properties. Benzoheterocycles such as …
diverse biological and pharmacological properties. Benzoheterocycles such as …
Organocatalytic asymmetric [4+ 2] cyclization of 2-benzothiazolimines with azlactones: access to chiral benzothiazolopyrimidine derivatives
Q Ni, X Wang, F Xu, X Chen, X Song - Chemical Communications, 2020 - pubs.rsc.org
An organocatalytic asymmetric domino Mannich/cyclization reaction between 2-
benzothiazolimines with azlactones has been successfully developed. With the bifunctional …
benzothiazolimines with azlactones has been successfully developed. With the bifunctional …
Harmine-inspired design and synthesis of benzo [d] imidazo [2, 1-b] thiazole derivatives bearing 1, 3, 4-oxadiazole moiety as potential tumor suppressors
T Zhao, Y Yang, J Yang, Y Cui, Z Cao, D Zuo… - Bioorganic & Medicinal …, 2021 - Elsevier
Standard chemotherapy and personalized target therapies are commonly used in patients
with advanced non-small cell lung cancer (NSCLC). However, multidrug resistance (MDR) …
with advanced non-small cell lung cancer (NSCLC). However, multidrug resistance (MDR) …
Rational design of novel potential EGFR inhibitors by 3D-QSAR, molecular docking, molecular dynamics simulation, and pharmacokinetics studies
The epidermal growth factor receptor (EGFR) is one of the most attractive drug targets
against the human pancreas cancer cell line (Panc-1). In this research, forty xanthine …
against the human pancreas cancer cell line (Panc-1). In this research, forty xanthine …
Selective halocyclization and iodosulfonylation of N-benzothiazol-2-yl alkynamides under mild conditions
Y Fang, S Ren, C He, H Han, JB Liu, F Liao… - Organic & Biomolecular …, 2022 - pubs.rsc.org
The selective halocyclization and iodosulfonylation of N-benzothiazol-2-yl alkynamides
under mild conditions is described. An effective synthetic strategy to pyrimidobenzothiazoles …
under mild conditions is described. An effective synthetic strategy to pyrimidobenzothiazoles …