Mesenchymal stem cell (MSC)-derived exosomes as novel vehicles for delivery of miRNAs in cancer therapy

B Sohrabi, B Dayeri, E Zahedi, S Khoshbakht… - Cancer Gene …, 2022 - nature.com
Mesenchymal stem cells (MSCs) are known as promising sources for cancer therapy and
can be utilized as vehicles in cancer gene therapy. MSC-derived exosomes are central …

The role of the miR‐148/‐152 family in physiology and disease

M Friedrich, K Pracht, MF Mashreghi… - European journal of …, 2017 - Wiley Online Library
MicroRNAs (miRNAs) are endogenously encoded∼ 22 nt small non‐coding RNAs. They
function as key players of many cellular processes by base pairing with target mRNAs and …

FAK signaling in cancer-associated fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

HJ Wu, M Hao, SK Yeo, JL Guan - Oncogene, 2020 - nature.com
Cancer-associated fibroblasts (CAFs) are activated fibroblasts that constitute the major
components of tumor microenvironment (TME) and play crucial roles in tumor development …

Osteosarcoma cell-derived exosomes affect tumor microenvironment by specific packaging of microRNAs

L Raimondi, A De Luca, A Gallo, V Costa… - …, 2020 - academic.oup.com
Bone microenvironment provides growth and survival signals essential for osteosarcoma
(OS) initiation and progression. OS cells regulate communications inside tumor …

miRNA-148a-3p regulates immunosuppression in DNA mismatch repair–deficient colorectal cancer by targeting PD-L1

M Ashizawa, H Okayama, T Ishigame… - Molecular Cancer …, 2019 - AACR
Immunotherapy against the interaction between programmed cell death 1/programmed cell
death ligand 1 (PD-L1) has emerged as a promising strategy for colorectal cancer with …

Effects of therapeutic probiotics on modulation of microRNAs

A Davoodvandi, H Marzban, P Goleij… - Cell Communication and …, 2021 - Springer
Probiotics are beneficial bacteria that exist within the human gut, and which are also present
in different food products and supplements. They have been investigated for some decades …

miRNA-148a serves as a prognostic factor and suppresses migration and invasion through Wnt1 in non-small cell lung cancer

Y Chen, L Min, C Ren, X Xu, J Yang, X Sun, T Wang… - PloS one, 2017 - journals.plos.org
Lung cancer is the leading cause of cancer death in the world, and aberrant expression of
miRNA is a common feature during the cancer initiation and development. Our previous …

Synthesis of bleomycin-inspired RNA ligands targeting the biogenesis of oncogenic miRNAs

C Maucort, M Bonnet, JC Ortuno, G Tucker… - Journal of Medicinal …, 2023 - ACS Publications
Noncoding RNAs (ncRNAs) play pivotal roles in the regulation of gene expression and
represent a promising target for the development of new therapeutic approaches. Among …

Role of miRNAs in human cancer metastasis: Implications for therapeutic intervention

MA Jafri, MH Al-Qahtani, JW Shay - Seminars in cancer biology, 2017 - Elsevier
Metastasis is the spread and growth of localized cancer to new locations in the body and is
considered the main cause of cancer-related deaths. Metastatic cancer cells display distinct …

Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon tumor cells in a miRNA-dependent manner

S Reif, Y Elbaum Shiff, R Golan-Gerstl - Journal of translational medicine, 2019 - Springer
Background Breastfeeding is the ideal source of infant nutrition. Human milk consists not
only of nutrients but also biologically active components. Among these latter compounds …