[HTML][HTML] Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies

C Yao, S Wu, J Kong, Y Sun, Y Bai, R Zhu… - Cancer Biology & …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-associated death
worldwide. Angiogenesis, the process of formation of new blood vessels, is required for …

The tumor microenvironment of hepatocellular carcinoma and its targeting strategy by CAR-T cell immunotherapy

Z Guizhen, J Guanchang, L Liwen, W Huifen… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is the major subtype of liver cancer, which ranks sixth in
cancer incidence and third in mortality. Although great strides have been made in novel …

Electrospun tube reduces adhesion in rabbit Achilles tendon 12 weeks post-surgery without PAR-2 overexpression

GM Bürgisser, O Evrova, DM Heuberger, P Wolint… - Scientific Reports, 2021 - nature.com
One great challenge in surgical tendon repair is the minimization of peritendinous
adhesions. An electrospun tube can serve as a physical barrier around a conventionally …

Signaling crosstalk of TGF-β/ALK5 and PAR2/PAR1: a complex regulatory network controlling fibrosis and cancer

H Ungefroren, F Gieseler, R Kaufmann… - International journal of …, 2018 - mdpi.com
Both signaling by transforming growth factor-β (TGF-β) and agonists of the G Protein-
coupled receptors proteinase-activated receptor-1 (PAR1) and-2 (PAR2) have been linked …

Syndecan-1 promotes angiogenesis in triple-negative breast cancer through the prognostically relevant tissue factor pathway and additional angiogenic routes

E Nassar, N Hassan, EA El-Ghonaimy, H Hassan… - Cancers, 2021 - mdpi.com
Simple Summary Triple-negative breast cancer is an aggressive subtype of breast cancer
characterized by tumor angiogenesis and poor patient survival. Here, we analyzed the …

An imbalance between stellate cells and γδT cells contributes to hepatocellular carcinoma aggressiveness and recurrence

BY Zhou, JH Gong, XY Cai, JX Wang, F Luo… - Hepatology …, 2019 - Springer
Purpose The diagnostic potential of hepatic stellate cells (HSCs) and γδT cells for patients
with hepatocellular carcinoma (HCC) and their synergistic contributions to the prognosis of …

Proteinase-activated receptor 2 is a novel regulator of TGF-β signaling in pancreatic cancer

D Witte, F Zeeh, T Gädeken, F Gieseler… - Journal of Clinical …, 2016 - mdpi.com
TGF-β has a dual role in tumorigenesis, acting as a tumor suppressor in normal cells and in
the early stages of tumor development while promoting carcinogenesis and metastasis in …

Shear Stress Drives the Cleavage Activation of Protease‐Activated Receptor 2 by PRSS3/Mesotrypsin to Promote Invasion and Metastasis of Circulating Lung Cancer …

M Zhou, K Li, KQ Luo - Advanced Science, 2023 - Wiley Online Library
When circulating tumor cells (CTCs) travel in circulation, they can be killed by detachment‐
induced anoikis and fluidic shear stress (SS)‐mediated apoptosis. Circulatory treatment …

PRSS1 mutation: a possible pathomechanism of pancreatic carcinogenesis and pancreatic cancer

Q Liu, L Guo, S Zhang, J Wang, X Lin, F Gao - Molecular Medicine, 2019 - Springer
Background Previous studies revealed somatic mutations of the cationic trypsinogen gene
(PRSS1) in patients with chronic pancreatitis and pancreatic cancer. However, whether …

Leveraging tumor microenvironment infiltration in pancreatic cancer to identify gene signatures related to prognosis and immunotherapy response

J Yang, L Zeng, R Chen, L Huang, Z Wu, M Yu, Y Zhou… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) has an insidious onset and
rapid progression, and its morbidity and mortality are increasing year by year. Currently …