A comprehensive review on steroidal bioconjugates as promising leads in drug discovery

R Bansal, A Suryan - ACS bio & med Chem Au, 2022 - ACS Publications
Ever increasing unmet medical requirements of the human race and the continuous fight for
survival against variety of diseases give birth to novel molecules through research. As …

The changing metabolic landscape of bile acids–keys to metabolism and immune regulation

I Mohanty, C Allaband, H Mannochio-Russo… - Nature reviews …, 2024 - nature.com
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

2-Aminothiazole: A privileged scaffold for the discovery of anti-cancer agents

Y Wan, J Long, H Gao, Z Tang - European Journal of Medicinal Chemistry, 2021 - Elsevier
Cancer has been the second heath killer being next only to cardiovascular diseases in
human society. Although many efforts have been taken for cancer therapy and many …

Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids

H Huo, G Li, B Shi, J Li - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
Steroids modification for improving their biological activities is one of the most efficient and
fruitful methods to develop novel medicines. Steroids with aza-heterocycles attaching to the …

[HTML][HTML] Chemical conjugation in drug delivery systems

A Eras, D Castillo, M Suárez, NS Vispo… - Frontiers in …, 2022 - frontiersin.org
Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer
are usually so intense and invasive that they weaken the patient to cure as dangerous as the …

Design, synthesis, characterization and anticancer activity evaluation of deoxycholic acid-chalcone conjugates

S Patel, N Challagundla, RA Rajput, S Mishra - Bioorganic Chemistry, 2022 - Elsevier
A series of deoxycholic acid-chalcone amides were synthesised and tested against the
human lung cancer cell line, A549 and the cervical cancer cell line, SiHa. Among the …

[HTML][HTML] Amino-acid-conjugated natural compounds: aims, designs and results

H Arifian, R Maharani, S Megantara, AM Gazzali… - Molecules, 2022 - mdpi.com
Protein is one of the essential macronutrients required by all living things. The breakdown of
protein produces monomers known as amino acids. The concept of conjugating natural …

Main-Chain Cationic Bile Acid Polymers Mimicking Facially Amphiphilic Antimicrobial Peptides

C Lin, Z Ma, Y Gao, M Le, Z Shi, D Qi… - … Applied Materials & …, 2023 - ACS Publications
Antibiotic-resistant bacterial infections have led to an increased demand for antibacterial
agents that do not contribute to antimicrobial resistance. Antimicrobial peptides (AMPs) with …

Recent progress in bile acid-based antimicrobials

C Lin, Y Wang, M Le, KF Chen, YG Jia - Bioconjugate Chemistry, 2021 - ACS Publications
With the emergence of drug-resistant bacteria and the formation of biofilms by bacteria and
fungi, microbial infections gradually threaten global health. Natural antimicrobial peptides …

Promising applications of steroid сonjugates for cancer research and treatment

VА Zolottsev, АS Latysheva, VS Pokrovsky… - European Journal of …, 2021 - Elsevier
The conjugation of biologically active molecules is a powerful tool for drug discovery used to
target a variety of multifunctional diseases including cancer. Conjugated drugs can provide …