Filamentous fungi constitute a large group of eukaryotic microorganisms that grow by
forming simple tube-like hyphae that are capable of differentiating into more-complex …

Filamentous fungi produce a multitude of low molecular weight bioactive compounds. The
increasing number of fungal genome sequences impressively demonstrated that their …

Covering: up to 2013 Although holo-acyl carrier protein synthase, AcpS, a
phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until …

Background Secondary metabolite production, a hallmark of filamentous fungi, is an
expanding area of research for the Aspergilli. These compounds are potent chemicals …

Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4
methylation, activated the expression of cryptic secondary metabolite clusters in A. nidulans …

Meroterpenoids are a class of fungal natural products that are produced from polyketide and
terpenoid precursors. An understanding of meroterpenoid biosynthesis at the genetic level …

Xanthones are a class of molecules that bind to a number of drug targets and possess a
myriad of biological properties. An understanding of xanthone biosynthesis at the genetic …

The recently sequenced genomes of several Aspergillus species have revealed that these
organisms have the potential to produce a surprisingly large range of natural products, many …

The sequencing of Aspergillus genomes has revealed that the products of a large number of
secondary metabolism pathways have not yet been identified. This is probably because …

Fungi utilize a phosphorelay system coupled to a MAP kinase module for sensing and
processing environmental signals. In Aspergillus nidulans, response regulator SskA …