Involvement of life stress in Late-Onset Alzheimer's Disease (LOAD) has been evinced in
longitudinal cohort epidemiological studies, and endocrinologic evidence suggests …

Signaling from the synapse to nucleus is mediated by the integration and propagation of
both membrane potential changes (postsynaptic potentials) and intracellular second …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and …

Introduction Alzheimer's disease (AD) is the most prevalent cause of dementia, and
emerging evidence suggests that ferroptosis is involved in the pathological process of AD …

Retrograded starch is known to be resistant to digestion. We used enzyme kinetic
experiments to examine how retrogradation of starch affects amylolysis catalysed by porcine …

Individuals with intact cognition and neuropathology consistent with Alzheimer's disease
(AD) are referred to as asymptomatic AD (AsymAD). These individuals are highly likely to …

Finding early disease markers using non-invasive and widely available methods is essential
to develop a successful therapy for Alzheimer's Disease. Few studies to date have examined …

Background Alzheimer's disease (AD) is the most common neurodegenerative disorder.
Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological …

In recent years, the move to study neurodegenerative disease using larger animal models
with brains that are more similar to humans has gained interest. While pigs have been used …

Novel drug development is onerous, time consuming and overpriced process with
particularly low success and relatively high enfeebling rates. To overcome this burden, drug …