Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Recent neuroscience research has established the adult brain as a dynamic organ having a
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …

Neuroimmune cross-talk participates in intestinal tissue homeostasis and host defense.
However, the matrix of interactions between arrays of molecularly defined neuron subsets …

Chemotherapy-induced peripheral neuropathy (CIPN) and associated neuropathic pain is a
debilitating adverse effect of cancer treatment. Current understanding of the mechanisms …

Understanding the endogenous mechanisms regulating resolution of pain may identify
novel targets for treatment of chronic pain. Resolution of chemotherapy-induced peripheral …

Chemotherapy-induced peripheral neuropathy (CIPN), characterized by pain and numbness
in hands and feet, is a common side effect of cancer treatment. In most patients, symptoms of …

BACKGROUND: Gut microbiota, a consortium of diverse microorganisms residing in the
gastrointestinal tract, has emerged as a key player in neuroinflammatory responses …

The immune system is critically involved in the development and maintenance of chronic
pain. However, T cells, one of the main regulators of the immune response, have only …

Chronic pain is a major debilitating condition that is difficult to treat. Although chronic pain
may appear to be a disorder of the nervous system, crucial roles for immune cells and their …

Chronic pain remains an unresolved problem. Current treatments have limited efficacy.
Thus, novel therapeutic targets are urgently required for the development of more effective …