Gastric cancer is a deadly malignancy afflicting close to a million people worldwide. Patient
survival is poor and largely due to late diagnosis and suboptimal therapies. Disease …

Tumour suppressor gene inactivation is critical to the pathogenesis of cancers; such loss of
function may be mediated by irreversible processes such as gene deletion or mutation …

Loss of function of the E-cadherin gene (CDH1) has been linked with diffuse gastric cancer
susceptibility, and germline inactivating mutations in CDH1 characterise the hereditary …

The development and progression of gastric cancer involves a number of genetic and
epigenetic alterations of tumor suppressor and tumor-related genes. The majority of …

Aberrant hypermethylation of promoter CpG islands is an important mechanism for the
inactivation of tumor suppressor genes. CpG island hypermethylation occurs in relation to …

Background Endoscopic resection (ER) has been widely accepted in Japan as a less
invasive treatment for early gastric cancer, but the incidence of subsequent metachronous …

BACKGROUND & AIMS: By using methylation-sensitive representational difference
analysis, we identified protocadherin 10 (PCDH10), a gene that encodes a protocadherin …

Age-related methylation may have the potential to behave as a mutator process. To clarify
the physiological consequence of age-related methylation of tumor suppressor and tumor …

Introduction: The tumor suppressor genes RASSF1A, APC, H-cadherin, RARβ2, and cyclin
D2 are methylated more frequently in breast cancer than in adjacent benign tissue …

Several attempts to classify gastric cancer (GCA) have been made over the past decades.
Most successful, and widely used, is the classification by Laurén, which distinguishes, by …