A metal‐free tandem procedure by using a sulfonylation reaction of aryl allylic alcohols
followed by an iodobenzenediacetate (PIDA)‐promoted oxidative functionalization has been …

Scientists working in the field of Alzheimer's disease and, in particular, cognitive enhancers
are very productive. The review on Drugs interacting with Enzymes was accepted in August …

Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

We disclose here the first iodine/tert‐butyl hydroperoxide (I2/TBHP)‐mediated benzylic C–H
sulfonylation of phenol derivatives. This new methodology provides an economic …

Catalytic asymmetric 1, 4-addition reactions of alkanesulfonamides were developed on the
'product base'strategy. Alkanesulfonamides reacted with α, β-unsaturated amides in good to …

Accumulation of the β-amyloid (Aβ) peptides is one of the major pathologic hallmarks in the
brains of Alzheimer's disease (AD) patients. Aβ is generated by sequential proteolytic …

Disease-modifying approaches for the treatment or prevention of Alzheimer's disease (AD)
are urgently needed. A hallmark pathology of AD is the presence of amyloid plaques in the …

Alzheimer's disease (AD) is the most common cause of dementia in late life. Currently there
are no effective treatments available for this devastating disease. The amyloid hypothesis is …

Attempts to block metabolism by incorporating a 9-fluoro substituent at the A-ring of
compound 1 (SCH 900229) using electrophilic Selectfluor™ led to an unexpected oxidation …