Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
Fungal infections are a major contributor to infectious disease-related deaths across the
globe. Candida species are among the most common causes of invasive mycotic disease …
globe. Candida species are among the most common causes of invasive mycotic disease …
Treatment strategies for cryptococcal infection: challenges, advances and future outlook
Cryptococcus spp., in particular Cryptococcus neoformans and Cryptococcus gattii, have an
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
enormous impact on human health worldwide. The global burden of cryptococcal meningitis …
Amphotericin B and other polyenes—Discovery, clinical use, mode of action and drug resistance
Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …
Antifungal drugs: the current armamentarium and development of new agents
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
and morbidity, particularly for immunocompromised populations. The fungal pathogens …
Combinatorial strategies for combating invasive fungal infections
Invasive fungal infections are an important cause of human mortality and morbidity,
particularly for immunocompromised populations. However, there remains a paucity of …
particularly for immunocompromised populations. However, there remains a paucity of …
Treatment of Cryptococcal meningitis: how have we got here and where are we going?
NTT Ngan, B Flower, JN Day - Drugs, 2022 - Springer
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
[HTML][HTML] Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms
P Van Dijck, J Sjollema, BPA Cammue, K Lagrou… - Microbial Cell, 2018 - ncbi.nlm.nih.gov
Unlike superficial fungal infections of the skin and nails, which are the most common fungal
diseases in humans, invasive fungal infections carry high morbidity and mortality …
diseases in humans, invasive fungal infections carry high morbidity and mortality …
Fungal Lanosterol 14α-demethylase: A target for next-generation antifungal design
The cytochrome P450 enzyme lanosterol 14α-demethylase (LDM) is the target of the azole
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
antifungals used widely in medicine and agriculture as prophylaxis or treatments of …
Molecular mechanisms governing antifungal drug resistance
Fungal pathogens are a severe public health problem. The leading causative agents of
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
systemic fungal infections include species from the Candida, Cryptococcus, and Aspergillus …
Characterization of Aspergillus fumigatus Extracellular Vesicles and Their Effects on Macrophages and Neutrophils Functions
JAM Souza, LM Baltazar, VM Carregal… - Frontiers in …, 2019 - frontiersin.org
Extracellular vesicles (EVs) has been considered an alternative process for intercellular
communication. EVs release by filamentous fungi and the role of vesicular secretion during …
communication. EVs release by filamentous fungi and the role of vesicular secretion during …