Biginelli reaction involves acid-catalyzed one-pot synthesis of 3, 4-dihydropyrimidin-2 (1 H)-
ones (DHPMs) using easily-accessible starting materials, namely, aldehyde, active …

The current manuscript describes the importance, mechanism propositions, evidence and
controversies associated with multicomponent reactions (MCRs). The following …

Sustainable or green chemistry has established firm ground providing essential design
criteria for the development of efficient chemical syntheses of complex, high added value …

The recently developed artificial force induced reaction (AFIR) method was applied to
search systematically all possible multicomponent pathways for the Biginelli reaction …

The present work describes the synthesis, characterization, and application of a new ion‐
tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive …

Multicomponent reactions are considered to be of increasing importance as time progresses
due to the economic and environmental advantages such strategies entail. The three …

Highlights•Ionic liquid effects over multicomponent reactions are described.•Ion-pairing
effects do play a role.•Reaction mechanisms are influenced by the ionic liquid …

The current manuscript describes the role and importance of catalysis and solvent effects for
the Biginelli multicomponent reaction. The overwhelming number of new catalysts and …

We review the most innovative efforts and greatest challenges faced when elucidating
multicomponent reactions (MCRs) mechanisms. When compared to traditional reactions, the …

Herein, a combination of heteropolyacids and ionic liquids as a catalytic system was studied
for the Biginelli multicomponent reaction; the positive ionic liquid effect associated with the …