Adenosine receptor antagonists: Recent advances and therapeutic perspective

A Saini, R Patel, S Gaba, G Singh, GD Gupta… - European Journal of …, 2022 - Elsevier
Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

If small molecules immunotherapy comes, can the prime be far behind?

J Zhang, Y Zhang, B Qu, H Yang, S Hu… - European Journal of …, 2021 - Elsevier
Anti-cancer immunotherapy, which includes cellular immunotherapy, immune checkpoint
inhibitors and cancer vaccines, has transformed the treatment strategies of several …

Medicinal chemistry and therapeutic potential of agonists, antagonists and allosteric modulators of A1 adenosine receptor: current status and perspectives

PK Deb, S Deka, P Borah, SN Abed… - Current Pharmaceutical …, 2019 - ingentaconnect.com
Adenosine is a purine nucleoside, responsible for the regulation of a wide range of
physiological and pathophysiological conditions by binding with four G-protein-coupled …

Ionic Liquid Modified SPION@Chitosan as a Novel and Reusable Superparamagnetic Catalyst for Green One-Pot Synthesis of Pyrido[2,3-d]pyrimidine-dione …

MH Sayahi, A Sepahdar, F Bazrafkan, F Dehghani… - Catalysts, 2023 - mdpi.com
In this paper, the chitosan-functionalized ionic liquid is modified with superparamagnetic
iron oxide nanoparticles to form a novel and reusable catalyst (SPION@ CS-IL), which was …

Therapeutic potential of agonists and antagonists of A1, A2a, A2b and A3 adenosine receptors

S Jamwal, A Mittal, P Kumar… - Current …, 2019 - ingentaconnect.com
Adenosine is a naturally occurring nucleoside and an essential component of the energy
production and utilization systems of the body. Adenosine is formed by the degradation of …

Adenosine A2A receptor as a potential drug target-current status and future perspectives

OHA Al-Attraqchi, M Attimarad… - Current …, 2019 - ingentaconnect.com
Adenosine receptors (ARs) are a class of G-protein coupled receptors (GPCRs) that are
activated by the endogenous substance adenosine. ARs are classified into 4 subtype …

7‐Amino‐2‐aryl/hetero‐aryl‐5‐oxo‐5,8‐dihydro[1,2,4]triazolo[1,5‐a]pyridine‐6‐carbonitriles: Synthesis and adenosine receptor binding studies

K Shaik, PK Deb, RP Mailavaram… - Chemical biology & …, 2019 - Wiley Online Library
A series of novel 7‐amino‐5‐oxo‐2‐substituted‐aryl/hetero‐aryl‐5, 8‐dihydro [1, 2, 4]
triazolo [1, 5‐a] pyridine‐6‐carbonitriles (4a–4t) was synthesized, characterized and …

P1 receptor agonists/antagonists in clinical trials-potential drug candidates of the future

P Borah, S Deka, RP Mailavaram… - Current pharmaceutical …, 2019 - ingentaconnect.com
Background: Adenosine mediates various physiological and pathological conditions by
acting on its four P1 receptors (A1, A2A, A2B and A3 receptors). Omnipresence of P1 …

Adenosine receptors in modulation of central nervous system disorders

H Choudhury, DK Chellappan… - Current …, 2019 - ingentaconnect.com
The ubiquitous signaling nucleoside molecule, adenosine is found in different cells of the
human body to provide its numerous pharmacological role. The associated actions of …

Adenosine receptors as novel targets for the treatment of various cancers

B Gorain, H Choudhury, GS Yee… - Current …, 2019 - ingentaconnect.com
Adenosine is a ubiquitous signaling nucleoside molecule, released from different cells
within the body to act on vasculature and immunoescape. The physiological action on the …