Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The
uptake and metabolism of amino acids are aberrantly upregulated in many cancers that …

Tumor cells harbor genetic alterations that promote a continuous and elevated production of
reactive oxygen species. Whereas such oxidative stress conditions would be harmful to …

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as
a promising target for cancer therapy. However, efforts to drug this process are confounded …

Metabolic reprogramming is widely observed during cancer development to confer cancer
cells the ability to survive and proliferate, even under the stressed, such as nutrient-limiting …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Glutamine is an abundant and versatile nutrient that participates in energy formation, redox
homeostasis, macromolecular synthesis, and signaling in cancer cells. These characteristics …

Alternative modes of metabolism enable cells to resist metabolic stress. Inhibiting these
compensatory pathways may produce synthetic lethality. We previously demonstrated that …

Rapidly proliferating cancer cells require energy and cellular building blocks for their growth
and ability to maintain redox balance. Many studies have focused on understanding how …

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …