Sleep is universal, tightly regulated, and its loss impairs cognition. But why does the brain
need to disconnect from the environment for hours every day? The synaptic homeostasis …

Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing
substantial distress for both people with dementia and their caregivers, and contributing to …

Rapid eye movement (REM) sleep is associated with the consolidation of emotional
memories. Yet, the underlying neocortical circuits and synaptic mechanisms remain unclear …

Over more than a century of research has established the fact that sleep benefits the
retention of memory. In this review we aim to comprehensively cover the field of “sleep and …

Sleep function remains controversial. Individual perspectives frame the issue of sleep
function differently. We briefly illustrate how sleep measurement and the evolution, tissue …

The role of peripheral physiology in the experience of emotion has been debated since the
19th century following the seminal proposal by William James that somatic responses to …

Alzheimer's disease is the most prevalent cause of dementia, which is defined by the
combined presence of amyloid and tau, but researchers are gradually moving away from the …

Sleep disruption appears to be a core component of Alzheimer's disease (AD) and its
pathophysiology. Signature abnormalities of sleep emerge before clinical onset of AD …

Clear associations of sleep, cognitive performance, and behavioral problems have been
demonstrated in meta-analyses of studies in adults. This meta-analysis is the first to …

Fatigue can have a major impact on an individual's performance and wellbeing, yet is poorly
understood, even within the scientific community. There is no developed theory of its origins …