ATP, besides an intracellular energy source, is an agonist when applied to a variety of
different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are …

Neocortical neuroblast cell lines were used to clone G-protein-coupled receptor (GPCR)
genes to study signaling mechanisms regulating cortical neurogenesis. One putative GPCR …

The understanding of the nucleotide/P2 receptor system in the regulation of renal
hemodynamics and transport function has grown exponentially over the last 20 yr. This …

Cholera toxin (CT) elicits a mucosal immune response in mice when used as a vaccine
adjuvant. The mechanisms by which CT exerts its adjuvant effects are incompletely …

Although the effects of nucleotides in the cardiovascular system have been known for almost
70 years, it is only in the past few years that some of the P2 receptors at which they act have …

The determinants of" basal" activity of signaling pathways regulating cellular responses are
poorly defined. One possibility is that cells release factors to establish the set-point of such …

Extracellular nucleotides (eg, ATP) regulate physiological and pathophysiological processes
through activation of nucleotide P2 receptors in the plasma membrane. Examples include …

1 Using equivalent short circuit current (ISC) measurements we examined the effect of
extracellular ATP on transepithelial ion transport in M‐1 mouse cortical collecting duct cells …

P 2 receptor subtypes and their signaling mechanisms were characterized in dispersed
smooth muscle cells. UTP and ATP stimulated inositol 1, 4, 5-triphosphate formation, Ca 2+ …

HM74A is a G protein-coupled receptor for nicotinic acid (niacin), which has been used
clinically to treat dyslipidemia for decades. The molecular mechanisms whereby niacin …