The mechanical properties of crystalline materials are crucial knowledge for their screening,
design, and exploitation. Density functional theory (DFT), remains one of the most effective …

The mechanical properties of energetic crystals (ECs) are relevant to the safety and
performance of ammunitions and propellants. Several experimental and theoretical …

Cocrystallization is a widely accepted and clinically relevant technique that has prospered
very well over the past decades to potentially modify the physicochemical properties of …

The objectives of this study were to prepare and characterize a novel piperine–succinic acid
multicomponent crystal phase and to evaluate the improvement in the solubility and …

Pharmaceutical salt formation is the most preferred and effective method to enhance the
physicochemical properties of an active pharmaceutical ingredient (API) such as solubility …

Pharmaceutical co-crystals present an opportunity to improve the solubility of conventional
active pharmaceutical ingredients (APIs). Despite advances in co-crystal screening, the …

Dicarboxylic acids (DiAs) are probably among of the most popular cocrystal formers. Due to
the high hydrophilicity and nontoxicity, they are promising solubilizers of active …

In this study, we attempt to simultaneously improve the photostability and solubility of
epalrestat (a drug used for neuropathy treatment) by preparing epalrestat–betaine …

Benexate, a drug used clinically as a defensive type anti-ulcer agent, has poor solubility and
a bitter taste. To improve its solubility, a crystal engineering approach was proposed with the …

The mechanical properties of powders determine the ease of manufacture and ultimately the
quality of the oral solid dosage forms. Although poor mechanical properties of an active …