Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …
Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research
P Bolaños, JC Calderón - Frontiers in Physiology, 2022 - frontiersin.org
The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …
link between the membrane excitation and the mechanical contraction. The initiation and …
Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice
The purpose of this study is to determine whether moderate aerobic exercise training
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …
Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle
Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders
characterized by progressive muscle wasting and often premature death. The primary defect …
characterized by progressive muscle wasting and often premature death. The primary defect …
Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …
DNA transfection of mammalian skeletal muscles using in vivo electroporation
M DiFranco, M Quinonez, J Capote… - Journal of visualized …, 2009 - pmc.ncbi.nlm.nih.gov
A growing interest in cell biology is to express transgenically modified forms of essential
proteins (eg fluorescently tagged constructs and/or mutant variants) in order to investigate …
proteins (eg fluorescently tagged constructs and/or mutant variants) in order to investigate …
Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (EC) coupling
Defective coupling between sarcoplasmic reticulum and mitochondria during control of
intracellular Ca 2+ signaling has been implicated in the progression of neuromuscular …
intracellular Ca 2+ signaling has been implicated in the progression of neuromuscular …
Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy
DC Andersson, AC Meli, S Reiken, MJ Betzenhauser… - Skeletal muscle, 2012 - Springer
Background Disruption of the sarcolemma-associated dystrophin-glycoprotein complex
underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy …
underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy …
Theaflavin promotes mitochondrial abundance and glucose absorption in myotubes by activating the CaMKK2-AMPK signal axis via calcium-ion influx
Z Qu, A Liu, C Liu, Q Tang, L Zhan, W Xiao… - Journal of Agricultural …, 2021 - ACS Publications
Drinking tea has been proven to have a positive biological effect in regulating human
glucose and lipid metabolism and preventing type 2 diabetes (T2D). Skeletal muscle (SkM) …
glucose and lipid metabolism and preventing type 2 diabetes (T2D). Skeletal muscle (SkM) …
Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy
M García-Castañeda, A Michelucci, N Zhao… - Journal of General …, 2022 - rupress.org
Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …