Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies

S Mareedu, ED Million, D Duan, GJ Babu - Frontiers in physiology, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research

P Bolaños, JC Calderón - Frontiers in Physiology, 2022 - frontiersin.org
The excitation–contraction coupling (ECC) in skeletal muscle refers to the Ca2+-mediated
link between the membrane excitation and the mechanical contraction. The initiation and …

Moderate aerobic exercise training ameliorates impairment of mitochondrial function and dynamics in skeletal muscle of high‐fat diet‐induced obese mice

JW Heo, MH No, J Cho, Y Choi, EJ Cho… - The FASEB …, 2021 - Wiley Online Library
The purpose of this study is to determine whether moderate aerobic exercise training
improves high‐fat diet‐induced alterations in mitochondrial function and structure in the …

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

SA Goonasekera, CK Lam, DP Millay… - The Journal of …, 2011 - Am Soc Clin Investig
Muscular dystrophies (MDs) comprise a group of degenerative muscle disorders
characterized by progressive muscle wasting and often premature death. The primary defect …

Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis

J Zhou, J Yi, R Fu, E Liu, T Siddique, E Ríos… - Journal of Biological …, 2010 - ASBMB
Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder characterized by
degeneration of motor neurons and atrophy of skeletal muscle. Mutations in the superoxide …

DNA transfection of mammalian skeletal muscles using in vivo electroporation

M DiFranco, M Quinonez, J Capote… - Journal of visualized …, 2009 - pmc.ncbi.nlm.nih.gov
A growing interest in cell biology is to express transgenically modified forms of essential
proteins (eg fluorescently tagged constructs and/or mutant variants) in order to investigate …

Mitochondrial calcium uptake regulates rapid calcium transients in skeletal muscle during excitation-contraction (EC) coupling

J Yi, C Ma, Y Li, N Weisleder, E Ríos, J Ma… - Journal of Biological …, 2011 - ASBMB
Defective coupling between sarcoplasmic reticulum and mitochondria during control of
intracellular Ca 2+ signaling has been implicated in the progression of neuromuscular …

Leaky ryanodine receptors in β-sarcoglycan deficient mice: a potential common defect in muscular dystrophy

DC Andersson, AC Meli, S Reiken, MJ Betzenhauser… - Skeletal muscle, 2012 - Springer
Background Disruption of the sarcolemma-associated dystrophin-glycoprotein complex
underlies multiple forms of muscular dystrophy, including Duchenne muscular dystrophy …

Theaflavin promotes mitochondrial abundance and glucose absorption in myotubes by activating the CaMKK2-AMPK signal axis via calcium-ion influx

Z Qu, A Liu, C Liu, Q Tang, L Zhan, W Xiao… - Journal of Agricultural …, 2021 - ACS Publications
Drinking tea has been proven to have a positive biological effect in regulating human
glucose and lipid metabolism and preventing type 2 diabetes (T2D). Skeletal muscle (SkM) …

Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy

M García-Castañeda, A Michelucci, N Zhao… - Journal of General …, 2022 - rupress.org
Duchenne muscular dystrophy (DMD), an X-linked disorder caused by loss-of-function
mutations in the dystrophin gene, is characterized by progressive muscle degeneration and …