Intracranial atherosclerotic stenosis (ICAS) is one of the most frequent causes of stroke
worldwide and confers one of the greatest risks of recurrent stroke compared with other …

With over 2 million new cases annually, stroke is associated with the highest disability-
adjusted life-years lost of any disease in China. The burden is expected to increase further …

Background The role of endovascular therapy for acute stroke with a large infarction has not
been extensively studied in differing populations. Methods We conducted a multicenter …

Importance Prior randomized trials have generally shown harm or no benefit of stenting
added to medical therapy for patients with symptomatic severe intracranial atherosclerotic …

Background Alteplase is the standard agent used in early reperfusion therapy, but
alternative thrombolytic agents are needed. The efficacy and safety of reteplase as …

Importance Prior trials of extracranial-intracranial (EC-IC) bypass surgery showed no benefit
for stroke prevention in patients with atherosclerotic occlusion of the internal carotid artery …

Importance In-stent restenosis (ISR) is the primary reason for stroke recurrence after
intracranial stenting in patients who were treated with a standard bare-metal stent (BMS) …

Large vessel occlusion stroke due to underlying intracranial atherosclerotic disease (ICAD-
LVO) is prevalent in 10 to 30% of LVOs depending on patient factors such as vascular risk …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

Objective: We aimed to investigate whether the efficacy and safety of clopidogrel plus aspirin
vs aspirin alone were consistent between patients with and without intracranial arterial …