Cheating evolution: engineering gene drives to manipulate the fate of wild populations
Engineered gene drives—the process of stimulating the biased inheritance of specific genes—
have the potential to enable the spread of desirable genes throughout wild populations or to …
have the potential to enable the spread of desirable genes throughout wild populations or to …
Wolbachia and the biological control of mosquito‐borne disease
Mosquito‐borne diseases such as malaria, dengue fever and filariasis cause an enormous
health burden to people living in tropical and subtropical regions of the world. Despite years …
health burden to people living in tropical and subtropical regions of the world. Despite years …
A Wolbachia symbiont in Aedes aegypti limits infection with dengue, Chikungunya, and Plasmodium
LA Moreira, I Iturbe-Ormaetxe, JA Jeffery, G Lu… - Cell, 2009 - cell.com
Wolbachia are maternally inherited intracellular bacterial symbionts that are estimated to
infect more than 60% of all insect species. While Wolbachia is commonly found in many …
infect more than 60% of all insect species. While Wolbachia is commonly found in many …
Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti
CJ McMeniman, RV Lane, BN Cass, AWC Fong… - Science, 2009 - science.org
Most pathogens require a relatively long period of development in their mosquito vector
before they can be transmitted to a new human host; hence, only older insects are of …
before they can be transmitted to a new human host; hence, only older insects are of …
Immune Activation by Life-Shortening Wolbachia and Reduced Filarial Competence in Mosquitoes
Wolbachia strain w MelPop reduces the longevity of its Drosophila melanogaster host and,
when introduced into the mosquito Aedes aegypti, halves its life span. We show that w …
when introduced into the mosquito Aedes aegypti, halves its life span. We show that w …
Wolbachia Stimulates Immune Gene Expression and Inhibits Plasmodium Development in Anopheles gambiae
The over-replicating w MelPop strain of the endosymbiont Wolbachia pipientis has recently
been shown to be capable of inducing immune upregulation and inhibition of pathogen …
been shown to be capable of inducing immune upregulation and inhibition of pathogen …
Heritable strategies for controlling insect vectors of disease
A Burt - Philosophical Transactions of the Royal Society …, 2014 - royalsocietypublishing.org
Mosquito-borne diseases are causing a substantial burden of mortality, morbidity and
economic loss in many parts of the world, despite current control efforts, and new …
economic loss in many parts of the world, despite current control efforts, and new …
Spatial waves of advance with bistable dynamics: cytoplasmic and genetic analogues of Allee effects
Unlike unconditionally advantageous “Fisherian” variants that tend to spread throughout a
species range once introduced anywhere,“bistable” variants, such as chromosome …
species range once introduced anywhere,“bistable” variants, such as chromosome …
Wolbachia and cytoplasmic incompatibility in mosquitoes
SP Sinkins - Insect biochemistry and molecular biology, 2004 - Elsevier
Wolbachia are maternally inherited bacteria that induce cytoplasmic incompatibility in
mosquitoes, and are able to use these patterns of sterility to spread themselves through …
mosquitoes, and are able to use these patterns of sterility to spread themselves through …
Comparative analysis of gut microbiota of mosquito communities in central Illinois
Background The composition and structure of microbial communities that inhabit the
mosquito midguts are poorly understood despite their well-documented potential to impede …
mosquito midguts are poorly understood despite their well-documented potential to impede …