Small-molecule fluorescent probes are attractive and versatile materials for studying
biological systems.(1-6) They can be easily loaded into cells and rapidly detect biological …

T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

In search of foreign antigens, lymphocytes recirculate from the blood, through lymph nodes,
into lymphatics and back to the blood. Dendritic cells also migrate to lymph nodes for optimal …

Much has been learned about how cells enter lymphoid tissues. But how do they leave?
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …

Chemokines have a central role in regulating processes essential to the immune function of
T cells,,, such as their migration within lymphoid tissues and targeting of pathogens in sites …

Interactions between different cell types are essential for multiple biological processes,
including immunity, embryonic development and neuronal signalling. Although the …

The central nervous system (CNS) has historically been viewed as an immunologically
privileged site, but recent studies have uncovered a vast landscape of immune cells that …

A functional immune system depends on the appropriate activation of lymphocytes following
antigen encounter. In this Review, we summarize studies that have used high-resolution …

Everyday we turnover billions of cells. The quick, efficient, and immunologically silent
disposal of the dying cells requires a coordinated orchestration of multiple steps, through …

For more than 25 years, it has been widely appreciated that Ca2+ influx is essential to
trigger T‐lymphocyte activation. Patch clamp analysis, molecular identification, and …