Benzo [a] pyrene (B [a] P) is the main representative of polycyclic aromatic hydrocarbons
(PAHs), and has been repeatedly found in the air, surface water, soil, and sediments. It is …

TP53, a crucial tumor suppressor gene, is the most commonly mutated gene in human
cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often …

Combination immune checkpoint blockade has demonstrated promising benefit in lung
cancer, but predictors of response to combination therapy are unknown. Using whole-exome …

Cancer is a clonal disorder derived from a single ancestor cell and its progenies that are
positively selected by acquisition of 'driver mutations'. However, the evolution of positively …

Chemotherapy is one of the most common treatments for cancer that uses one or more anti-
cancer drugs as a part of the standardized chemotherapy regimen. Cytotoxic chemicals …

Tobacco smoking causes lung cancer,–, a process that is driven by more than 60
carcinogens in cigarette smoke that directly damage and mutate DNA,. The profound effects …

Summary Whole-genome-sequencing (WGS) of human tumors has revealed distinct
mutation patterns that hint at the causative origins of cancer. We examined mutational …

Purpose: Although clinical studies have shown promise for targeting programmed cell death
protein-1 (PD-1) and ligand (PD-L1) signaling in non–small cell lung cancer (NSCLC), the …

Immune checkpoint inhibitors, which unleash a patient's own T cells to kill tumors, are
revolutionizing cancer treatment. To unravel the genomic determinants of response to this …

ABSTRACT TP53 gene mutations are one of the most frequent somatic events in cancer.
The IARC TP53 Database (http://p53. iarc. fr) is a popular resource that compiles occurrence …