[HTML][HTML] Reprogramming of glucose metabolism: the hallmark of malignant transformation and target for advanced diagnostics and treatments

Q Tang, S Wu, B Zhao, Z Li, Q Zhou, Y Yu… - Biomedicine & …, 2024 - Elsevier
Reprogramming of cancer metabolism has become increasingly concerned over the last
decade, particularly the reprogramming of glucose metabolism, also known as the" Warburg …

Role of cell division cycle-associated proteins in regulating cell cycle and promoting tumor progression

Z Wang, M Ren, W Liu, J Wu, P Tang - Biochimica et Biophysica Acta (BBA) …, 2024 - Elsevier
The cell division cycle-associated protein (CDCA) family is important in regulating cell
division. High CDCA expression is significantly linked to tumor development. This review …

Multi-omic approaches to breast cancer metabolic phenotyping: Applications in diagnosis, prognosis, and the development of novel treatments

N Gómez-Cebrián, I Domingo-Ortí, JL Poveda… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer (BC) is a heterogeneous tumor type and has become the
leading cause of cancer worldwide, with 685,000 deaths forecast in 2020. The clinical …

Comprehensive analysis of the expression and prognosis value of chromobox family members in clear cell renal cell carcinoma

Y Zhu, Z Pu, Z Li, Y Lin, N Li, F Peng - Frontiers in oncology, 2021 - frontiersin.org
Clear cell renal cell carcinoma (ccRCC) accounts for 80% of all renal cancers and has a
poor prognosis. Chromobox (CBX) family protein expression has been reported in a variety …

Molecular mechanisms of multi-omic regulation in breast cancer

S Ochoa, E Hernández-Lemus - Frontiers in Oncology, 2023 - frontiersin.org
Breast cancer is a complex disease that is influenced by the concurrent influence of multiple
genetic and environmental factors. Recent advances in genomics and other high throughput …

The epigenetic regulatory protein CBX2 promotes mTORC1 signalling and inhibits DREAM complex activity to drive breast cancer cell growth

LJ Bilton, C Warren, RM Humphries, S Kalsi, E Waters… - Cancers, 2022 - mdpi.com
Simple Summary Cancer develops due to the expression of genes that promote cell growth
and the repression of genes that limit growth. Epigenetics is a mechanism that regulates …

Metabolic stratification of human breast tumors reveal subtypes of clinical and therapeutic relevance

MA Iqbal, S Siddiqui, K Smith, P Singh, B Kumar… - Iscience, 2023 - cell.com
Extensive metabolic heterogeneity in breast cancers has limited the deployment of
metabolic therapies. To enable patient stratification, we studied the metabolic landscape in …

[HTML][HTML] Chromobox proteins in cancer: Multifaceted functions and strategies for modulation

J Wang, B Yang, X Zhang, S Liu… - International …, 2023 - spandidos-publications.com
Chromobox (CBX) proteins are important epigenetic regulatory proteins and are widely
involved in biological processes, such as embryonic development, the maintenance of stem …

CBX7 is dualistic in cancer progression based on its function and molecular interactions

J Li, T Ouyang, M Li, T Hong, MHS Alriashy… - Frontiers in …, 2021 - frontiersin.org
Chromobox protein homolog 7 (CBX7) is a member of the Chromobox protein family and
participates in the formation of the polycomb repressive complex 1 (PRC1). In cells, CBX7 …

Subcellular expression pattern and clinical significance of CBX2 and CBX7 in breast cancer subtypes

S Park, J Choi, JK Song, B Jang, YH Maeng - Medical Molecular …, 2024 - Springer
Abstract Chromobox (CBX) 2 and CBX7, members of CBX family protein, show diverse
expression patterns and contrasting roles in certain cancers. We aimed to investigate the …