Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of
continuous cell expansion until the cytomembrane ruptures, resulting in the release of …

Pyroptosis is a lytic and inflammatory type of programmed cell death that is usually triggered
by inflammasomes and executed by gasdermin proteins. The main characteristics of …

Gasdermins were recently identified as the mediators of pyroptosis—inflammatory cell death
triggered by cytosolic sensing of invasive infection and danger signals. Upon activation …

The adoptive transfer of T cells that are engineered to express chimeric antigen receptors
(CARs) has shown remarkable success in treating B cell malignancies but only limited …

For over three decades, a mainstay and goal of clinical oncology has been the development
of therapies promoting the effective elimination of cancer cells by apoptosis. This …

Soft robotics technologies are paving the way toward robotic abilities which are vital for a
wide range of applications, including manufacturing, manipulation, gripping, human …

Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments
causes inflammatory cell death (pyroptosis). Gasdermin E (GSDME, also known as DFNA5) …

INTRODUCTION In cellular immunity, cytotoxic T lymphocytes (CTLs) and natural killer (NK)
cells use perforin to deliver serine protease granzymes into target cells to kill them …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-
tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells …