Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

For tumor treatment, the ultimate goal in tumor therapy is to eliminate the primary tumor,
manage potential metastases, and trigger an antitumor immune response, resulting in the …

Background Keratitis ichthyosis deafness (KID) syndrome is a rare disorder caused by
hemichannel (HC) activating gain-of-function mutations in the GJB2 gene encoding …

Connexin (Cx) hemichannels (HCs) are large pore hexameric structures that allow the
exchange of ions, metabolites and a variety of other molecules between the cell cytoplasm …

Intercellular communication plays a crucial role in cancer, as well as other diseases, such as
inflammation, tissue degeneration, and neurological disorders. One of the proteins …

Photodynamic therapy (PDT) is a therapeutic modality based on the simultaneous action of
three elements: photosensitizer, light and oxygen. This triad generates singlet oxygen and …

Increasing evidence points to deregulated flux of ionized calcium (Ca2+) mediated by
hyperactive mutant connexin (Cx) hemichannels (HCs) as a common gain-of-function …

Stable cell pools have the advantage of providing a definite, consistent, and reproducible
transmission of a transgene of interest, compared to transient expression from a plasmid …

Multimodal microscopy combines multiple non-linear techniques that take advantage of
different optical processes to generate contrast and increase the amount of information that …

The modern paradigm of studying the processes of carcinogenesis and vital activity of tumor
tissues implies increased attention to constituents of tumor microenvironment (TME) and …