Investigations of carcinogenesis have evolved from the identification of clonal driver
mutations in candidate genes to the integration of large volumes of genomic and …

By 2030, it is expected that a billion people will have suffer from obesity. Adipose tissue
synthesizes leptin, an adipokine that affects cardiovascular risk. Leptin intensifies the …

Colorectal cancer (CRC) is one of the most common and deadly malignancies. Novel
biomarkers for the diagnosis and prognosis of this disease must be identified. Besides …

Conventional therapies for metastatic cancers have limited efficacy. Recently, cancer
therapies targeting noncancerous cells in tumor microenvironments have shown improved …

Purpose: Preclinical studies show that antiangiogenic therapy exacerbates tumor glycolysis
and activates liver kinase B1/AMP kinase (AMPK), a pathway involved in the regulation of …

We assessed if leptin, a cytokine hormone known to enhance energy expenditure by
promoting lipid and carbohydrate catabolism in response to physiologic stress, might directly …

Resistance to platinum-based chemotherapy represents a major clinical challenge for many
tumors, including epithelial ovarian cancer. Patients often experience several response …

Microbiome modulation is one of the novel strategies in medicine with the greatest future to
improve the health of individuals and reduce the risk of different conditions, including …

Abstract Background Mitochondrial DNA (mtDNA) pathogenic variants have been reported
in several solid tumors including ovarian cancer (OC), the most lethal gynecologic …

The most common cancer in women is breast cancer, which is also the second leading
cause of death in this group. It is, however, important to note that some women will develop …