Epileptogenesis
A Pitkänen, K Lukasiuk… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …
[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …
Role of blood–brain barrier in temporal lobe epilepsy and pharmacoresistance
EA Van Vliet, E Aronica, JA Gorter - Neuroscience, 2014 - Elsevier
Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies in adults. It is
often initiated by an insult or brain injury which triggers a series of alterations which …
often initiated by an insult or brain injury which triggers a series of alterations which …
The enigma of the latent period in the development of symptomatic acquired epilepsy—traditional view versus new concepts
A widely accepted hypothesis holds that there is a seizure-free, pre-epileptic state, termed
the “latent period”, between a brain insult, such as traumatic brain injury or stroke, and the …
the “latent period”, between a brain insult, such as traumatic brain injury or stroke, and the …
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice
S Klein, M Bankstahl, W Löscher - Neuropharmacology, 2015 - Elsevier
Despite more than 20 clinically approved antiepileptic drugs (AEDs), there remains a
substantial unmet clinical need for patients with refractory (AED-resistant) epilepsy. Animal …
substantial unmet clinical need for patients with refractory (AED-resistant) epilepsy. Animal …
The relevance of inter-and intrastrain differences in mice and rats and their implications for models of seizures and epilepsy
It is becoming increasingly clear that the genetic background of mice and rats, even in
inbred strains, can have a profound influence on measures of seizure susceptibility and …
inbred strains, can have a profound influence on measures of seizure susceptibility and …
Astrocytic CD44 Deficiency Reduces the Severity of Kainate-Induced Epilepsy
PK Kruk, K Nader, A Skupien-Jaroszek, T Wójtowicz… - Cells, 2023 - mdpi.com
Background: Epilepsy affects millions of people worldwide, yet we still lack a successful
treatment for all epileptic patients. Most of the available drugs modulate neuronal activity …
treatment for all epileptic patients. Most of the available drugs modulate neuronal activity …
Significant effects of sex, strain, and anesthesia in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy
The intrahippocampal kainate mouse model of mesial temporal lobe epilepsy is increasingly
being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous …
being used for studies on epileptogenesis and antiepileptogenesis. Almost all previous …
A face‐to‐face comparison of the intra‐amygdala and intrahippocampal kainate mouse models of mesial temporal lobe epilepsy and their utility for testing novel …
Objective Intracranial (intrahippocampal or intra‐amygdala) administration of kainate in
rodents leads to spatially restricted brain injury and development of focal epilepsy with …
rodents leads to spatially restricted brain injury and development of focal epilepsy with …
Dynamics of PDGFRβ expression in different cell types after brain injury
Platelet‐derived growth factor receptor β (PDGFRβ) is upregulated after brain injury and its
depletion results in the blood–brain barrier (BBB) damage. We investigated the time …
depletion results in the blood–brain barrier (BBB) damage. We investigated the time …