Brain development in humans is achieved through precise spatiotemporal genetic control,
the mechanisms of which remain largely elusive. Recently, integration of technological …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

The forces of evolution—mutation, selection, migration, and genetic drift—shape the genetic
architecture of human traits, including the genetic architecture of complex neuropsychiatric …

Cis-regulatory elements (CREs) control gene expression, orchestrating tissue identity,
developmental timing, and stimulus responses, which collectively define the thousands of …

Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises
five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003 …

One of the foundational aims of human genetics is understanding the genetic causes of
human traits, with a particular focus on disease. Two decades after the publication of the …

Improving the diversity and quality of genome assemblies for non-human mammals has
been a long-standing goal of comparative genomics. The last year saw substantial progress …

As humans' closest living relatives, chimpanzees offer valuable insights into human
evolution. However, technical and ethical limitations hinder investigations into the molecular …

Background Genetic changes that modify the function of transcriptional enhancers have
been linked to the evolution of biological diversity across species. Multiple studies have …