Primary brain and central nervous system (CNS) tumors are a diverse group of neoplasms
that occur within the brain and spinal cord. Although significant advances in our …

Abstract Background Childhood brain tumours (CBTs) are the leading cause of cancer death
in children under the age of 20 years globally. Though the aetiology of CBT remains poorly …

The O-6-methylguanine-DNA methyltransferase (MGMT) gene is a critical guardian of
genomic integrity. MGMT methylation in diffuse gliomas serves as an important determinant …

The lesson from many studies investigating the efficacy of targeted therapy in glioblastoma
(GBM) showed that a future perspective should be focused on combining multiple target …

Introduction We aimed to evaluate the changing patterns in the management of glioblastoma
(GBM) and impact on survival outcomes over a 20year period. Methods This is a …

Background: Understanding sex-based differences in glioblastoma patients is necessary for
accurate personalized treatment planning to improve patient outcomes. Purpose: To …

Gliomas are a group of heterogeneous tumors that account for substantial morbidity,
mortality, and costs to patients and healthcare systems globally. Survival varies considerably …

In 2015, a groundswell of brain tumour patient, carer and charity activism compelled the UK
Minister for Life Sciences to form a brain tumour research task and finish group. This …

Glioblastoma (GB), a prevalent and highly malignant primary brain tumour with a very high
mortality rate due to its resistance to conventional therapies and invasive nature, resulting in …

OBJECTIVE Wide disparities in neurosurgical oncology care and treatment outcomes exist
globally despite recent improvements in diagnostics and cancer therapy. To better …