Parkinson's disease (PD) is an incurable, devastating disorder that is characterized by
pathological protein aggregation and neurodegeneration in the substantia nigra. In recent …

The pathological aggregation of the presynaptic protein α-synuclein (α-syn) and propagation
through synaptically coupled neuroanatomical tracts is increasingly thought to underlie the …

Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can
propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients …

Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …

A key hallmark of Parkinson's disease (PD) is Lewy pathology. Composed of α-synuclein,
Lewy pathology is found both in dopaminergic neurons that modulate motor function, and …

Alpha-synuclein (α-syn) is a small protein composed of 140 amino acids and belongs to the
group of intrinsically disordered proteins. It is a soluble protein that is highly expressed in …

Aggregation of α-synuclein (α-syn) is the cornerstone of neurodegenerative diseases termed
synucleinopathies, which include Parkinson's Disease (PD), Dementia with Lewy Bodies …

In patients with amyotrophic lateral sclerosis (ALS), disease symptoms and pathology
typically spread in a predictable spatiotemporal pattern beginning at a focal site of onset and …

Parkinson's disease (PD) and Alzheimer's disease (AD) are characterized by pathological
accumulation and aggregation of different amyloidogenic proteins, α-synuclein (aSyn) in PD …

Neurogenesis is a key mechanism of brain development and plasticity, which is impaired in
chronic neurodegeneration, including Parkinson's disease. The accumulation of aberrant α …