MicroRNAs as potential orchestrators of Alzheimer's disease-related pathologies: insights on current status and future possibilities

NZ Abuelezz, FE Nasr, MA AbdulKader… - Frontiers in Aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a progressive and deleterious neurodegenerative disease,
strongly affecting the cognitive functions and memory of seniors worldwide. Around 58% of …

microRNAs as early biomarkers of Alzheimer's disease: A synaptic perspective

D Siedlecki-Wullich, AJ Miñano-Molina… - Cells, 2021 - mdpi.com
Pathogenic processes underlying Alzheimer's disease (AD) affect synaptic function from
initial asymptomatic stages, long time before the onset of cognitive decline and …

Neuronal extracellular vesicles and associated microRNAs induce circuit connectivity downstream BDNF

A Antoniou, L Auderset, L Kaurani, E Sebastian… - Cell reports, 2023 - cell.com
Extracellular vesicles (EVs) have emerged as mediators of cellular communication, in part
via the delivery of associated microRNAs (miRNAs), small non-coding RNAs that regulate …

MicroRNA-dependent control of neuroplasticity in affective disorders

HC Martins, G Schratt - Translational Psychiatry, 2021 - nature.com
Affective disorders are a group of neuropsychiatric disorders characterized by severe mood
dysregulations accompanied by sleep, eating, cognitive, and attention disturbances, as well …

Dendritic spine and synaptic plasticity in Alzheimer's disease: a focus on MicroRNA

EE Reza-Zaldivar, MA Hernández-Sápiens… - Frontiers in Cell and …, 2020 - frontiersin.org
Dendrites and dendritic spines are dynamic structures with pivotal roles in brain connectivity
and have been recognized as the locus of long-term synaptic plasticity related to cognitive …

MiR-218: a molecular switch and potential biomarker of susceptibility to stress

A Torres-Berrío, D Nouel, S Cuesta, EM Parise… - Molecular …, 2020 - nature.com
Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of
depression. Here we assessed whether miR-218 in the mPFC confers resilience or …

Development of in vitro 2D and 3D microelectrode arrays and their role in advancing biomedical research

CM Didier, A Kundu, D DeRoo… - … of Micromechanics and …, 2020 - iopscience.iop.org
The development of microelectrode arrays (MEAs) along with complementary advances in
electronics, mechanics and software to connect with these arrays has led to the in vitro …

MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence

A Morgunova, C Flores - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we examine the role of microRNAs in the development of the prefrontal cortex
(PFC) in adolescence and in individual differences in vulnerability to mental illness. We …

The molecular mechanism of baicalein repressing progression of gastric cancer mediating miR-7/FAK/AKT signaling pathway

D Qiao, J Xing, Y Duan, S Wang, G Yao, S Zhang, J Jin… - Phytomedicine, 2022 - Elsevier
Background Baicalein (BAI) has a significant anti-cancerous function in the treatment of
gastric cancer (GC). Focal adhesion kinase (FAK) is a key regulatory molecule in integrin …

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF

F Buffolo, V Petrosino, M Albini, M Moschetta… - Cell death & …, 2021 - nature.com
Neuroinflammation is associated with synapse dysfunction and cognitive decline in patients
and animal models. One candidate for translating the inflammatory stress into structural and …