Antiplatelet drugs serve as a first-line antithrombotic therapy for the management of acute
ischemic events and the prevention of secondary complications in vascular diseases …

Abstract Phosphodiesterase 5 (PDE-5) is a major isoform of cGMP phosphodiesterase in
diverse tissues and plays a critical role in regulating intracellular cGMP concentrations …

Sildenafil is a potent phosphodiesterase-5 (PDE5) inhibitor that effectively inhibits cGMP
and increases the strength of nitric oxide. PDE5 was overexpressed in several carcinomas …

Phosphodiesterase (PDE) inhibitors–such as vardenafil–are used primarily for treating
erectile dysfunction via increasing cyclic guanosine monophosphate (cGMP) levels. Recent …

BACKGROUND: Sildenafil and Moringa appear to have the ability to reduce the ulcerogenic
effect of the drugs used to induce ulcers in rats. AIM: The present study was conducted to …

The regulation by immune checkpoint is able to prevent excessive tissue damage caused by
ischemia reperfusion (I/R); therefore, the study aims to investigate the behavior of …

Inflammatory bowel disease is a progressive inflammatory intestinal disease characterized
by colon tissue edema and increased epithelial permeability of colon and extensive …

Background Randomized skin flaps are extensively used in plastic surgery, but the
possibility of necrosis has challenged their use. Several studies have been conducted …

Endothelial dysfunction and vascular reactivity defects secondary to metabolic and
immunological disorders carry risk of serious cardiovascular complications. Here, the effects …

Background: Intra abdominal adhesions are a complication that occurs after many
abdominal surgical procedures, especially gynecological operations. These complications …