During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the
immune phenotypes of mice bred and maintained in conventional laboratory conditions …

The two most common tests for determining metabolic health in mice are the glucose
tolerance test (GTT) and insulin tolerance test (ITT). GTTs and ITTs are inexpensive and …

Obesity results from a caloric imbalance between energy intake, absorption and
expenditure. In both rodents and humans, diet-induced thermogenesis contributes to energy …

The molecular mediator and functional significance of meal-associated brown fat (BAT)
thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non …

Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some
adult humans, residuals of brown adipose tissue are adjacent to the central nervous system …

Human and mouse thermal physiology differ due to dissimilar body sizes. Unexpectedly, in
mice we found no ambient temperature zone where both metabolic rate and body …

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy
expenditure, has been extensively studied as a potential avenue to combat obesity …

Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis
reduces thermogenesis and causes obesity. However, whether creatine import from the …

Immunity to infection has been extensively studied in humans and mice bearing naturally
occurring or experimentally introduced germline mutations. Mouse studies are sometimes …