Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

The zebrafish is a leading model for studies of vertebrate development and genetics. Its
embryonic motor behaviors are easy to assess (eg for mutagenic screens), the embryos …

Larval zebrafish (Brachydanio rerio) are a popular model system because of their genetic
attributes, transparency and relative simplicity. They have approximately 200 neurons that …

Homozygous SMN1 loss causes spinal muscular atrophy (SMA), the most common lethal
genetic childhood motor neuron disease. SMN1 encodes SMN, a ubiquitous housekeeping …

We have observed the development of live, fluorescently labeled motoneurons in the spinal
cord of embryonic and larval zebrafish. There are 2 classes of motoneurons: primary and …

The programmed cell death (PCD) of developing cells is considered an essential adaptive
process that evolved to serve diverse roles. We review the putative adaptive functions of …

Motor neuron diseases (MNDs) are an etiologically heterogeneous group of disorders of
neurodegenerative origin, which result in degeneration of lower (LMNs) and/or upper motor …

Over the past few years, a number of studies have described the generation of transgenic
lines of zebrafish in which expression of reporters was driven by a variety of promoters …

Animals move over a range of speeds by using rhythmic networks of neurons located in the
spinal cord,,,,,. Here we use electrophysiology and in vivo imaging in larval zebrafish (Danio …

The major goal of developmental neurobiology is to understand how the nervous system is
put together. A central theme that has emerged from research in this field over the last …