A systematic literature review was undertaken to determine if conditioned pain modulation
(CPM) is reliable. Longitudinal, English language observational studies of the repeatability …

There is tremendous interpatient variability in the response to analgesic therapy (even for
efficacious treatments), which can be the source of great frustration in clinical practice. This …

The reviewed literature refines the methodology used for eliciting CPM responses and
characterizing their physiological attributes in healthy individuals and pain patients, and …

Studies have suggested that quantitative sensory testing (QST) might hold a predictive value
for the development of chronic postoperative pain and the response to pharmacological …

Conditioned pain modulation (CPM) is a centrally processed measure of the net effect of the
descending pain pathway. This comprises both the facilitatory as well as the inhibitory effect …

Diabetic peripheral neuropathy (DPN) is the most common complication of both type 1 and 2
diabetes. As a result, neuropathic pain, diabetic foot ulcers and lower-limb amputations …

The nociceptive system adapts readily to the varying needs of a warning system for
maintenance of bodily integrity. It often decreases its sensitivity upon continuous …

Background Persistent postoperative pain (PPP) is common after total knee arthroplasty
(TKA). The primary aim of this prospective cohort study was to identify important predictors of …

Chronic musculoskeletal pain is linked with sensitization, and standardized methods for
assessment are needed. This study investigated (1) the test–retest reliability of computer …

Objective: Conditioned pain modulation (CPM) responses may be affected by psychological
factors such as anxiety, depression, and pain catastrophizing; however, most studies on …