[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Insights into the fate of antibiotics in constructed wetland systems: Removal performance and mechanisms

M Lv, D Zhang, X Niu, J Ma, Z Lin, M Fu - Journal of Environmental …, 2022 - Elsevier
Antibiotics have been recognized as emerging contaminants that are widely distributed and
accumulated in aquatic environment, posing a risk to ecosystem at trace level. Constructed …

Mastering the Gram-negative bacterial barrier–Chemical approaches to increase bacterial bioavailability of antibiotics

HK Ropponen, R Richter, AKH Hirsch… - Advanced Drug Delivery …, 2021 - Elsevier
To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

I Negut, B Bita - Gels, 2023 - mdpi.com
AI and ML have emerged as transformative tools in various scientific domains, including
hydrogel design. This work explores the integration of AI and ML techniques in the realm of …

Functional Materials to Overcome Bacterial Barriers and Models to Advance Their Development

A Bali, MAM Kamal, G Mulla, B Loretz… - Advanced Functional …, 2023 - Wiley Online Library
With the emerging problem of antimicrobial resistance, the world is facing a slow but
dangerous pandemic. While the discovery of novel antibiotics is reaching a nearly …

Bone-Adhesive Hydrogel for Effective Inhibition of M. tuberculosis and Osteoblast Regeneration

S Mehnath, M Sathish Kumar, K Chitra… - ACS Infectious …, 2023 - ACS Publications
Currently, bone tuberculosis (TB) treatment largely involves lifelong drug prescriptions and
surgical intervention, resulting in poor quality of life for patients. Therefore, the fabrication of …

Sensing of antibiotic–bacteria interactions

AA Baranova, AP Tyurin, VA Korshun, VA Alferova - Antibiotics, 2023 - mdpi.com
Sensing of antibiotic–bacteria interactions is an important area of research that has gained
significant attention in recent years. Antibiotic resistance is a major public health concern …

Machine learning for soft and liquid molecular materials

T Orlova, A Piven, D Darmoroz, T Aliev, TMTA Razik… - Digital …, 2023 - pubs.rsc.org
This review discusses three types of soft matter and liquid molecular materials, namely
hydrogels, liquid crystals and gas bubbles in liquids, which are explored with an emergent …

Biophysical properties of hydrogels for mimicking tumor extracellular matrix

AP Cameron, B Zeng, Y Liu, H Wang… - Biomaterials …, 2022 - Elsevier
The extracellular matrix (ECM) is an essential component of the tumor microenvironment. It
plays a critical role in regulating cell-cell and cell-matrix interactions. However, there is lack …

Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds–A perspective

R Richter, CM Lehr - Advanced Drug Delivery Reviews, 2021 - Elsevier
Sudden outbreaks of novel infectious diseases and the persistent evolution of antimicrobial
resistant pathogens make it necessary to develop specific tools to quickly understand …