Measuring and interpreting transposable element expression
S Lanciano, G Cristofari - Nature Reviews Genetics, 2020 - nature.com
Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …
The dynamism of transposon methylation for plant development and stress adaptation
Plant development processes are regulated by epigenetic alterations that shape nuclear
structure, gene expression, and phenotypic plasticity; these alterations can provide the plant …
structure, gene expression, and phenotypic plasticity; these alterations can provide the plant …
LINE-1 expression in cancer correlates with p53 mutation, copy number alteration, and S phase checkpoint
W McKerrow, X Wang… - Proceedings of the …, 2022 - National Acad Sciences
Retrotransposons are genomic DNA sequences that copy themselves to new genomic
locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon …
locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon …
LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities
C Mendez-Dorantes, KH Burns - Genes & development, 2023 - genesdev.cshlp.org
Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …
active in humans. LINE-1 propagates in the genome using RNA intermediates via …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
Demystifying emerging bulk RNA-Seq applications: the application and utility of bioinformatic methodology
Significant innovations in next-generation sequencing techniques and bioinformatics tools
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …
have impacted our appreciation and understanding of RNA. Practical RNA sequencing …
Autonomous transposons tune their sequences to ensure somatic suppression
Transposable elements (TEs) are a major constituent of human genes, occupying
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
approximately half of the intronic space. During pre-messenger RNA synthesis, intronic TEs …
[HTML][HTML] Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
S Lanciano, C Philippe, A Sarkar, D Pratella… - Cell Genomics, 2024 - cell.com
Summary Long interspersed element 1 (L1) retrotransposons are implicated in human
disease and evolution. Their global activity is repressed by DNA methylation, but …
disease and evolution. Their global activity is repressed by DNA methylation, but …
IRescue: uncertainty-aware quantification of transposable elements expression at single cell level
B Polimeni, F Marasca, V Ranzani… - Nucleic Acids …, 2024 - academic.oup.com
Transposable elements (TEs) are mobile DNA repeats known to shape the evolution of
eukaryotic genomes. In complex organisms, they exhibit tissue-specific transcription …
eukaryotic genomes. In complex organisms, they exhibit tissue-specific transcription …
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic
element in both humans and mice, comprising almost 20% of each genome. L1s are …
element in both humans and mice, comprising almost 20% of each genome. L1s are …