Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance
to conventional therapies, including temozolomide, the most widely used chemotherapeutic …

Simple Summary In this review, the thorny issue of glioblastoma models is addressed, with a
focus on 3D in vitro models. In the first part of the manuscript, glioblastoma features and …

The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …

Glioblastoma (GBM), the most common and aggressive primary brain tumor in adults,
remains one of the least treatable cancers. Current standard of care—combining surgical …

Purpose Glioblastoma (GBM) is the most common invasive malignant brain tumour in adults.
It is traditionally investigated in vitro by culturing cells as a monolayer (2D culture) or as …

The complexity and diversity of the biochemical processes that occur during tumorigenesis
and metastasis are frequently over-simplified in the traditional in vitro cell cultures. Two …

Cancer treatment is challenged by the heterogeneous nature of cancer, where prognosis
depends on tumor type and disease stage, as well as previous treatments. Optimal patient …

Background Glioblastoma (GBM) patients are notoriously difficult to treat and ultimately all
succumb to disease. This unfortunate scenario motivates research into better characterizing …

After leukemia, tumors of the brain and spine are the second most common form of cancer in
children. Despite advances in treatment, brain tumors remain a leading cause of death in …

Alginate, a naturally occurring polysaccharide, has been widely used in cell encapsulation,
3D culture, cell therapy, tissue engineering, and regenerative medicine. Alginate's frequent …