Mechanisms of diabetes mellitus-induced bone fragility
N Napoli, M Chandran, DD Pierroz… - Nature Reviews …, 2017 - nature.com
The risk of fragility fractures is increased in patients with either type 1 diabetes mellitus
(T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in …
(T1DM) or type 2 diabetes mellitus (T2DM). Although BMD is decreased in T1DM, BMD in …
Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/RNS generation
Reactive oxidative species (ROS) toxicity remains an undisputed cause and link between
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …
Alzheimer's disease (AD) and Type-2 Diabetes Mellitus (T2DM). Patients with both AD and …
Diabetes, oxidative stress, and antioxidants: a review
AC Maritim, RA Sanders… - Journal of biochemical …, 2003 - Wiley Online Library
Increasing evidence in both experimental and clinical studies suggests that oxidative stress
plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are …
plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are …
Periodontal disease: associations with diabetes, glycemic control and complications
GW Taylor, WS Borgnakke - Oral diseases, 2008 - Wiley Online Library
Objective: This report reviews the evidence for adverse effects of diabetes on periodontal
health and periodontal disease on glycemic control and complications of diabetes. Design …
health and periodontal disease on glycemic control and complications of diabetes. Design …
Advanced glycation end products, diabetes, and bone strength
M Yamamoto, T Sugimoto - Current osteoporosis reports, 2016 - Springer
Diabetic patients have a higher fracture risk than expected by their bone mineral density
(BMD). Poor bone quality is the most suitable and explainable cause for the elevated …
(BMD). Poor bone quality is the most suitable and explainable cause for the elevated …
Role of advanced glycation end products in mobility and considerations in possible dietary and nutritional intervention strategies
JH Chen, X Lin, C Bu, X Zhang - Nutrition & metabolism, 2018 - Springer
Advanced glycation end products (AGEs), a group of compounds that are formed by non-
enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of …
enzymatic reactions between carbonyl groups of reducing sugars and free amino groups of …
Pathophysiology and management of type 2 diabetes mellitus bone fragility
C Eller-Vainicher, E Cairoli, G Grassi… - Journal of Diabetes …, 2020 - Wiley Online Library
Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of bone fragility
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …
The association between metabolic syndrome components and the development of atherosclerosis
A Aboonabi, RR Meyer, I Singh - Journal of human hypertension, 2019 - nature.com
Metabolic syndrome (MetS) is a collection of pathological conditions associated with
metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the …
metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the …
Advanced glycation end‐products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone
S Kume, S Kato, S Yamagishi, Y Inagaki… - Journal of Bone and …, 2005 - academic.oup.com
The impact of AGEs on human MSCs was studied. AGEs inhibited the proliferation of MSCs,
induced apoptosis, and prevented cognate differentiation into adipose tissue, cartilage, and …
induced apoptosis, and prevented cognate differentiation into adipose tissue, cartilage, and …
Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non‐osmotic pathways
S Botolin, LR McCabe - Journal of cellular biochemistry, 2006 - Wiley Online Library
Insulin dependent diabetes mellitus (IDDM; type I) is a chronic disease stemming from little
or no insulin production and elevated blood glucose levels. IDDM is associated with …
or no insulin production and elevated blood glucose levels. IDDM is associated with …