Diabetes and cognitive impairment: a role for glucotoxicity and dopaminergic dysfunction
FC Pignalosa, A Desiderio, P Mirra, C Nigro… - International journal of …, 2021 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia,
responsible for the onset of several long-term complications. Recent evidence suggests that …
responsible for the onset of several long-term complications. Recent evidence suggests that …
Dopamine circuit mechanisms of addiction-like behaviors
CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …
addiction is formalized as substance use disorder (SUD), with three primary symptom …
Dopamine: a potential substrate for synaptic plasticity and memory mechanisms
TM Jay - Progress in neurobiology, 2003 - Elsevier
It is only recently that a number of studies on synaptic plasticity in the hippocampus and
other brain areas have considered that a heterosynaptic modulatory input could be recruited …
other brain areas have considered that a heterosynaptic modulatory input could be recruited …
[HTML][HTML] Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated …
RM Santiago, J Barbieiro, MMS Lima… - Progress in Neuro …, 2010 - Elsevier
Depression is a frequently encountered non-motor feature of Parkinson's disease (PD) and it
can have a significant impact on patient's quality of life. Considering the differential …
can have a significant impact on patient's quality of life. Considering the differential …
The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis
Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase …
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase …
Comparison of bilaterally 6-OHDA-and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory …
MM Ferro, MI Bellissimo, JA Anselmo-Franci… - Journal of neuroscience …, 2005 - Elsevier
This study compares histological, neurochemical, behavioral, motor and cognitive
alterations as well as mortality of two models of Parkinson's disease in which 100μg 1 …
alterations as well as mortality of two models of Parkinson's disease in which 100μg 1 …
Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits
MM Carvalho, FL Campos, B Coimbra, JM Pêgo… - Molecular …, 2013 - Springer
Background Parkinson's disease (PD) is a chronic neurodegenerative condition that is
characterized by motor symptoms as a result of dopaminergic degeneration, particularly in …
characterized by motor symptoms as a result of dopaminergic degeneration, particularly in …
Animal models of the non-motor features of Parkinson's disease
K McDowell, MF Chesselet - Neurobiology of disease, 2012 - Elsevier
The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of
patients, have a profound negative impact on their quality of life, and often go undiagnosed …
patients, have a profound negative impact on their quality of life, and often go undiagnosed …
Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms
RDS Prediger - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
approximately 1% of the population older than 60 years. Classically, PD is considered to be …
approximately 1% of the population older than 60 years. Classically, PD is considered to be …
Toxin-induced experimental models of learning and memory impairment
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …
drug development and hence are an imperative part in the assessment of therapeutics …