Diabetes and cognitive impairment: a role for glucotoxicity and dopaminergic dysfunction

FC Pignalosa, A Desiderio, P Mirra, C Nigro… - International journal of …, 2021 - mdpi.com
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia,
responsible for the onset of several long-term complications. Recent evidence suggests that …

Dopamine circuit mechanisms of addiction-like behaviors

CL Poisson, L Engel, BT Saunders - Frontiers in Neural Circuits, 2021 - frontiersin.org
Addiction is a complex disease that impacts millions of people around the world. Clinically,
addiction is formalized as substance use disorder (SUD), with three primary symptom …

Dopamine: a potential substrate for synaptic plasticity and memory mechanisms

TM Jay - Progress in neurobiology, 2003 - Elsevier
It is only recently that a number of studies on synaptic plasticity in the hippocampus and
other brain areas have considered that a heterosynaptic modulatory input could be recruited …

[HTML][HTML] Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated …

RM Santiago, J Barbieiro, MMS Lima… - Progress in Neuro …, 2010 - Elsevier
Depression is a frequently encountered non-motor feature of Parkinson's disease (PD) and it
can have a significant impact on patient's quality of life. Considering the differential …

The effects of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) on the cognitive and motor functions in rodents: A systematic review and meta-analysis

A Narmashiri, M Abbaszadeh, A Ghazizadeh - … & Biobehavioral Reviews, 2022 - Elsevier
Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase …

Comparison of bilaterally 6-OHDA-and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory …

MM Ferro, MI Bellissimo, JA Anselmo-Franci… - Journal of neuroscience …, 2005 - Elsevier
This study compares histological, neurochemical, behavioral, motor and cognitive
alterations as well as mortality of two models of Parkinson's disease in which 100μg 1 …

Behavioral characterization of the 6-hydroxidopamine model of Parkinson's disease and pharmacological rescuing of non-motor deficits

MM Carvalho, FL Campos, B Coimbra, JM Pêgo… - Molecular …, 2013 - Springer
Background Parkinson's disease (PD) is a chronic neurodegenerative condition that is
characterized by motor symptoms as a result of dopaminergic degeneration, particularly in …

Animal models of the non-motor features of Parkinson's disease

K McDowell, MF Chesselet - Neurobiology of disease, 2012 - Elsevier
The non-motor symptoms (NMS) of Parkinson's disease (PD) occur in roughly 90% of
patients, have a profound negative impact on their quality of life, and often go undiagnosed …

Effects of caffeine in Parkinson's disease: from neuroprotection to the management of motor and non-motor symptoms

RDS Prediger - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
approximately 1% of the population older than 60 years. Classically, PD is considered to be …

Toxin-induced experimental models of learning and memory impairment

SV More, H Kumar, DY Cho, YS Yun… - International journal of …, 2016 - mdpi.com
Animal models for learning and memory have significantly contributed to novel strategies for
drug development and hence are an imperative part in the assessment of therapeutics …