Bone and skeletal muscle are integrated organs and their coupling has been considered
mainly a mechanical one in which bone serves as attachment site to muscle while muscle …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

BM adipocytes (BMAd) are a unique cell population derived from BM mesenchymal
progenitors and marrow adipogenic lineage precursors. Although they have long been …

The coordinated development and function of bone-forming (osteoblasts) and bone-
resorbing (osteoclasts) cells is critical for the maintenance of skeletal integrity and calcium …

The rising incidence of metabolic diseases worldwide has prompted renewed interest in the
study of intermediary metabolism and cellular bioenergetics. The application of modern …

Apelin/APJ is widely distributed in various tissues in the body and participates in the
regulation of physiological and pathological mechanisms such as autophagy, apoptosis …

A complex interplay of genetic, environmental, hormonal, and behavioral factors affect
skeletal development, several of which are associated with childhood fractures. Given the …

In prostate to bone metastases, the “vicious cycle” paradigm has been traditionally used to
illustrate how metastases manipulate the bone forming osteoblasts and resorbing …

Multiple myeloma is a plasma cell skeletal malignancy. While therapeutic agents such as
bortezomib and lenalidomide have significantly improved overall survival, the disease is …

It has been presumed that adipokines deriving from adipose tissue may play important roles
in bone metabolism. Omentin‐1, a novel adipokine, which is selectively expressed in …